脂肪细胞在乳腺癌发展及治疗中的相关作用机制研究进展  

Research progress on the effect of adipocytes on breast cancer development and treatment

作　　者：赵崇如 熊铭琛 张奇[1] 吴毅平[1] Zhao Chongru;Xiong Mingchen;Zhang Qi;Wu Yiping(Department of Plastic and Cosmetic Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院整形美容外科,武汉430030

出　　处：《中华整形外科杂志》2021年第10期1186-1191,共6页Chinese Journal of Plastic Surgery

基　　金：中国光华科技基金会项目(2019JZXM001)。

摘　　要：乳腺癌的发生发展取决于乳腺癌细胞和肿瘤微环境的交互作用。脂肪细胞既是乳腺间质细胞的组成成分,同时也是乳腺癌肿瘤微环境的重要组成部分。其中,位于乳腺癌浸润前沿的癌症相关脂肪细胞,能够通过分泌多种活性因子和相关机制参与乳腺癌的进展和转移。该文作者就脂肪细胞对乳腺癌发展及治疗作用相关机制研究进展进行了综述。The occurrence and development of breast cancer depend on the reciprocal effects between breast cancer cells and tumor microenvironment.Adipocytes are not only the component of breast interstitial cells,but also an important part of the tumor microenvironment in breast cancer.Among them,cancer-associated adipocytes,which are located at the invasive front of breast cancer,participate in the progression and metastasis of breast cancer by secreting multiple active factors and related mechanisms.The authors made a brief review on the mechanisms related to the development and therapeutic effects of adipocytes on breast cancer.

关 键 词：脂肪细胞 乳腺肿瘤 癌症相关脂肪细胞 乳房再造 

分 类 号：R737.9[医药卫生—肿瘤]