甘孜州高原藏族地区0~6岁儿童维生素A、D、E水平与海拔高度、季节变化等因素的相关分析  

Correlation analysis between vitamin A,D and E levels with the altitude,seasonal variation and other factors in children with 0-6 years old in Tibetan Plateau of Ganzi Prefecture

作　　者：黄萍[1] 林新梅[2] 王全生 柯刚[4] 魏正容 郭杜平 巴学国 袁永萧 王群 丁红燕 何茂云 先礼贵 张利萍[10] 王钰斐 虞连会 匡克洪 罗庆平[14] 陈竹[13] 李红梅[1] 罗晶[1] 徐义兰[1] Huang Ping;Lin Xinmei;Wang Quansheng;Ke Gang;Wei Zhengrong;Guo Duping;Ba Xueguo;Yuan Yongxiao;Wang Qun;Ding Hongyan;He Maoyun;Xian Ligui;Zhang Liping;Wang Yufei;Yu Lianhui;Kuang Kehong;Luo Qingping;Chen Zhu;Li Hongmei;Luo Jing;Xu Yilan(Department of Child Healthcare,Luzhou People′s Hospital,Luzhou 646100,Sichuan Province,China;Department of Blood Transfusion,Luzhou People′s Hospital,Luzhou 646100,Sichuan Province,China;Department of Rehabilitation,Luxian Hospital of TCM,Luxian 646100,Sichuan Province,China;Department of Pharmacy,Luzhou People′s Hospital,Luzhou 646100,Sichuan Province,China;Department of Pediatrics,the People′s Hospital in Daocheng,Daocheng 626000,Sichuan Province,China;Clinical Laboratory,the People′s Hospital of Daocheng,Daocheng 626000,Sichuan Province,China;Department of Pediatrics,the People′s Hospital of Xiangcheng,Xiangcheng 626000,Sichuan Province,China;Department of Surgery,the People′s Hospital of Xiangcheng,Xiangcheng 626000,Sichuan Province,China;Department of Pediatrics,the Second People′s Hospital of Luxian,Luxian 646100,Sichuan Province,China;Disinfecting Supply Division,People′s Hospital of Luxian County,Luxian 646100,Sichuan Province,China;Chengdu Harmony Health Medical Laboratory Co Ltd.,Chengdu 610000,China;Department of Neonatology,Luzhou People′s Hospital,Luzhou 646100,Sichuan Province,China;Clinical Laboratory,Luzhou People′s Hospital,Luzhou 646100,Sichuan Pro-vince,China;Department of Obstetrics,Luzhou People′s Hospital,Luzhou 646100,Sichuan Province,China)

机构地区：[1]泸州市人民医院儿童保健科,四川泸州646100 [2]泸州市人民医院输血科,四川泸州646100 [3]泸县中医医院康复科,四川泸县646100 [4]泸州市人民医院药剂科,四川泸州646100 [5]稻城县人民医院儿科,四川稻城626000 [6]稻城县人民医院检验科,四川稻城626000 [7]乡城县人民医院儿科,四川乡城626000 [8]乡城县人民医院外科,四川乡城626000 [9]泸县第二人民医院儿科,四川泸县646100 [10]泸县人民医院消毒供应室,四川泸县646100 [11]成都和合医学诊断技术有限公司中心实验室,610000 [12]泸州市人民医院新生儿科,四川泸州646100 [13]泸州市人民医院检验科,四川泸州646100 [14]泸州市人民医院产科,四川泸州646100

出　　处：《中华实用儿科临床杂志》2021年第22期1736-1741,共6页Chinese Journal of Applied Clinical Pediatrics

基　　金：四川省卫生和计划生育委员会科研课题资助项目(17PJ276)。

摘　　要：目的了解甘孜州高原藏族地区0~6岁儿童血清维生素A(Vit A)、维生素D(Vit D)25-羟维生素D[25-(OH)D]、维生素E(Vit E)水平情况,为政府有关部门对高原地区儿童健康体检,四病(小儿腹泻、营养性贫血、佝偻病、小儿肺炎)防治提供依据。方法对2017年4月至2019年4月在四川省甘孜州乡城县12个乡镇和稻城县14个乡镇参与体检的2122名0~6岁儿童,现场填写完成相关问卷、体格测量、静脉采血,采用高效液相色谱法检测血清Vit A、Vit E水平,采用高效液相色谱串联质谱法检测血清25-(OH)D水平。分析其与性别、年龄、季节变化、海拔高度之间的关系。结果2122名0~6岁儿童血清Vit A水平为(1.05±0.27)μmol/L、亚临床缺乏率为8.15%(173/2122例)、可疑亚临床缺乏率为45.99%(976/2122例);不同年龄、季度和海拔血清Vit A水平、亚临床缺乏率和可疑亚临床缺乏率差异均有统计学意义(均P<0.05)。血清25-(OH)D水平为(24.65±6.45)ng/L,缺乏率为6.03%(128/2122例),不足率为16.59%(352/2122例);不同年龄、季度血清25-(OH)D水平缺乏率和不足率差异均有统计学意义(均P<0.05)。血清Vit E水平为(7.81±1.74)mg/L,缺乏率为2.78%(59/2122例),不足率为29.59%(628/2122例);不同年龄、季度血清Vit E平均水平、缺乏率和不足率差异均有统计学意义(均P<0.05)。Vit A和25-(OH)D在1岁以前水平最低,缺乏率最明显。Vit E在>1~2岁最低,缺乏率和不足率最高。Vit A、25-(OH)D、Vit E水平受季节变化的影响明显,夏季水平显著高于春、秋、冬季。Vit A、25-(OH)D受海拔影响显著,在4 km以上海拔高度其水平最低。结论甘孜州高原藏族地区0~6岁儿童Vit A、25-(OH)D、Vit E整体水平低于平原地区,不同年龄段、季节、海拔Vit A、25-(OH)D、Vit E差异显著,与当地资源缺乏、母亲孕期营养和出生后摄入不足,当地季节和海拔变化造成的温度、光照等因素有关,需要在孕期开始做好合理补充,预�Objective To detect serum levels of vitamin A(Vit A),vitamin D(Vit D)25-hydroxy vitamin D[25-(OH)D]and vitamin E(Vit E)in children aged 0-6 years in Tibetan Plateau of Garzi Prefecture,thus providing references for physical examinations and prevention of 4 key diseases(rickets,malnutrition anemia,pneumonia and diarrhea)in children in plateau areas by relevant government departments.Methods A total of 2122 children who participated in physical examination in 12 townships of Xiangcheng County and 14 townships of Daocheng County,Garzi Tibetan Autonomous Prefecture,Sichuan Province from April 2017 to April 2019 with 0-6 years old were recruited for surveying physical measurements and collection of venous blood.Serum Vit A and Vit E levels were detected by high performance liquid chromatography.Serum levels of 25-(OH)D were detected by high performance liquid chromatography tandem mass spectrometry.The relationship between Vit A,Vit E and 25-(OH)D levels with the gender,age,seasonal change and altitude was analyzed.Results The serum Vit A level,subclinical Vit A deficiency rate and marginal vitamin A deficiency rate were(1.05±0.27)μmol/L,8.15%(173/2122 cases)and 45.99%(976/2122 cases),respectively in 2122 children with 0-6 years old.There were significant differences in the serum Vit A level,the subclinical Vit A deficiency rate and the marginal vitamin A deficiency rate in children with different ages,seasons and altitudes(all P<0.05).The serum level of 25-(OH)D and 25-(OH)D deficiency rate insufficient rate were(24.65±6.45)ng/L,6.03%(128/2122 cases)and 16.59%(352/2122 cases),respectively.There were significant differences in the serum level of 25-(OH)D,25-(OH)D deficiency rate and 25-(OH)D insufficient rate in children with different ages and seasons(all P<0.05).The mean serum Vit E level,Vit E deficiency rate and Vit E insufficient rate were(7.81±1.74)mg/L,2.78%(59/2122 cases)and 29.59%(628/2122 cases),respectively.There were significant differences in serum Vit E level,Vit E deficiency rate and Vit E insuffici

关 键 词：儿童 高原藏族 维生素A 25-羟维生素D 维生素E 海拔高度 季节变化 

分 类 号：R153.2[医药卫生—营养与食品卫生学]