Opalski综合征5例报告及文献复习  

Opalski syndrome:A report of 5 cases and literature review

作　　者：李海琦 孙晨思 刘海贝 陈凯丽 徐磊[1] 何金婷[1] LI Haqi;SUN Chensi;LIU Haibei;CHEN Kaili;XU Lei;HE Jinting(Department of Neurology,China-Japan Union Hospital,Jilin University,Changchun 130033,China;Department of Endocrinology,China-Japan Union Hospital,Jilin University,Changchun 130033,China)

机构地区：[1]吉林大学中日联谊医院神经内科,吉林长春130033 [2]吉林大学中日联谊医院内分泌科,吉林长春130033

出　　处：《吉林大学学报（医学版）》2021年第6期1544-1549,共6页Journal of Jilin University：Medicine Edition

基　　金：吉林省财政厅科研项目(2019SCZ010);吉林省卫计委科研项目(2019Q018)。

摘　　要：目的:分析Opalski综合征患者临床特点和发病机制,提高临床医师对该疾病的认识。方法:收集5例Opalski综合征患者的临床资料,并进行文献回顾,总结Opalski综合征病因及发病机制。结果:5例Opalski综合征患者均为男性,平均年龄为(58.00±15.96)岁,其中4例患者存在长期饮酒史,临床表现为不同程度的延髓背外侧综合征伴有病灶侧肢体瘫痪,磁共振弥散加权成像(DWI)提示均存在延髓部位的梗死灶,但磁共振血管造影(MRA)显示其责任血管不同,患者1为椎动脉夹层,患者2~4为小脑后下动脉闭塞,患者5为椎动脉闭塞,5例患者经过保守治疗后症状均有一定程度的好转,其中患者1经过神经介入治疗后症状明显好转。结论:男性Opalski综合征的发病率高于女性,其责任血管和发生病变的原因存在差异,临床医师需要根据病因选择不同的治疗方式,给予患者最有效的治疗。Objective:To analyze the clinical characteristics and pathogenesis and of Opalski syndrome,and to improve the clinicians’s understanding of the disease.Methods:The clinical data of 5 patients with Opalski syndrome were collected,and the literature was reviewed to summarize the etiology and pathogenesis.Results:All 5 patients with Opalski syndrome were male,with an average age of(58.00±15.96)years.Among them,4 patients had a long-term history of alcohol consumption,who presented different degrees of Wallenberg syndrome combined with focal limb paralysis.The magnetic resonance diffusion-weighted imaging(DWI)detection results indicated that there was infarction in the medulla oblongata,but the magnetic resonance angiography(MRA)detection results showed that the responsible vessels were different,which was the vertebral artery dissection in patient 1,posterior inferior cerebellar artery occlusion in patient 2-4,and vertebral artery occludsion in patient 5.All 5 patients had some degrees of improvement in their symptoms after conservative treatment.The symptoms of patient 1 were improved significantly after the neurointerventional therapy.Conclusion:The incidence of Opalski syndrome in men is higher than that in women,and the responsible vessels and the causes of diseases are different.The clinicians can choose different treatment methods according to the etiology in order to give the most effective treatment to the patients.

关 键 词：延髓背外侧综合征 WALLENBERG综合征 Opalski综合征 延髓梗死 肢体瘫痪 

分 类 号：R741.02[医药卫生—神经病学与精神病学] R743[医药卫生—临床医学]