XPC基因rs2279017位点多态性与食管癌易感性的研究  

A study of the polymorphisms of XPC rs2279017 and susceptibility of esophageal cancer

作　　者：段培芬 周燕 冯向先 DUAN Pei-fen;ZHOU Yan;FENG Xiang-xian(Department of Preventive Medicine,Changzhi Medical College,Changzhi 046000,China;Jincheng General Hospital,Jincheng 048006,China)

机构地区：[1]长治医学院公共卫生与预防医学系,长治046000 [2]晋城大医院,晋城048006

出　　处：《中华疾病控制杂志》2021年第10期1194-1197,共4页Chinese Journal of Disease Control & Prevention

基　　金：山西省高等学校哲学社会科学项目(2019W099);山西省软科学研究计划项目(2019041048-4)。

摘　　要：目的探讨着色性干皮病基因组C(xeroderma pigmentosum group C, XPC)位点多态与长治市食管癌的关系以及主要危险因素的交互作用。方法采用成组匹配病例对照研究的方法,对150例食管癌患者和176例对照者进行问卷调查,应用实时荧光定量聚合酶链反应方法(real-time polymerase chain reaction, RT-PCR)对XPC rs2279017进行多态性检测,采用SPSS 20.0软件对研究结果进行统计分析。结果正常人群中,XPC基因型频率(GG、GT、TT)分别为48.86%、42.05%、9.09%,食管癌患者中分别为29.33%、46.00%、24.67%,差异有统计学意义(χ^(2)=20.12,P<0.001);携带等位基因T发生食管癌的风险是携带等位基因G的2.11倍(OR=2.11, 95%CI:1.53~2.92,P<0.001);交互作用分析显示XPC突变基因T与饮酒具有协同作用(RERI=1.26,S=1.91,API=0.35)。结论 XPC rs2279017位点多态性可能与长治市食管癌的发生有关。Objective To investigate the relationship between the polymorphisms of xeroderma pigmentosum group C(XPC)rs2279017 and the susceptibility of esophageal cancer in Changzhi area and its interaction with major risk factors.Methods In this study,150 cases of esophageal cancer and 176 cases of control were selected to participate in the questionnaire survey,and the group case-control study was conducted.Then,the genotype of XPC rs2279017 was detected by quantitatire real-time PCR.The results were analyzed by SPSS 20.0.Results In the control group,the frequencies of XPC genotype(GG,GT,TT)were 48.86%,42.05%,9.09%,respectively.Among the esophageal cancer group,the rates were 29.33%,46.00%and 24.67%,respectively,and the difference was statistically significant(χ^(2)=20.12,P<0.001).The risk of esophageal cancer with allele T was 2.11 times that with allele G(OR=2.11,95%CI:1.53-2.92,P<0.001).In addition,interaction analysis showed that XPC mutant T had a synergistic effect on alcohol consumption(RERI=1.26,S=1.91,API=0.35).Conclusions Polymorphism of XPC rs2279017 may be related to the occurrence of esophageal cancer in Changzhi City.

关 键 词：食管癌 着色性干皮病基因组C 基因多态性 交互作用 

分 类 号：R735.1[医药卫生—肿瘤]