多发性骨髓瘤患者CD200的表达及与预后的关系  

Expression of CD200 in multiple myeloma and the relationship with prognosis

作　　者：王卫国[1] 冯玉虎[2] 许凌云[2] 王伟伟[1] 翟志敏[3] WANG Weiguo;FENG Yuhu;XU Lingyun;WANG Weiwei;ZHAI Zhimin(Department of Clinical Laboratory,Fuyang People's Hospital,Anhui Fuyang 236001,China;Department of Hematology,Fuyang People's Hospital,Anhui Fuyang 236001,China;the Second Affiliated Hospital of Anhui Medical University,Anhui Hefei 230601,China)

机构地区：[1]阜阳市人民医院检验科,安徽阜阳236001 [2]阜阳市人民医院血液科,安徽阜阳236001 [3]安徽医科大学第二附属医院,安徽合肥230601

出　　处：《现代肿瘤医学》2021年第23期4205-4208,共4页Journal of Modern Oncology

基　　金：国家自然科学基金项目(编号:81670179)。

摘　　要：目的:探讨CD200在多发性骨髓瘤(multiple myeloma,MM)中的表达及其与预后的关系。方法:选取初诊的MM患者71例,利用流式细胞术(FCM)检测MM细胞中CD200的表达,检测了其中40例患者外周血T细胞亚群百分比。收集受试者临床资料,通过随访获取总生存期(OS),采用Kaplan-Meier法绘制生存曲线、Cox比例风险回归分析CD200表达与MM患者预后的关系。结果:71例MM患者中,51例(71.8%)阳性表达CD200,20例(28.2%)不表达CD200。CD200^(+)MM患者CD4^(+)T百分比和CD4/CD8比值低于CD200-患者(P<0.05)。CD200^(-)MM患者中位总生存期(OS)为26.0(95%CI 18.7~33.2)个月,CD200^(+)患者中位OS时间未达到(χ^(2)=4.210,P=0.040)。CD200^(+)MM患者1年和2年的OS率为52.4%和52.4%,CD200^(-)MM患者1年和2年的OS率为87.2%和64.4%。Cox回归风险模型分析结果显示MM患者年龄>65岁[HR=4.145(95%CI 1.252~13.728),P=0.020]、CD200阳性[HR=2.617(95%CI 1.044~6.561),P=0.040]是独立于其他临床指标的预后危险因素。结论:MM患者CD200表达存在异质性,CD200阳性表达是MM患者OS的不良预后因素。Objective:To explore the CD200 expression in multiple myeloma(MM)and its relationship with prognosis.Methods:The expression of CD200 was tested in 71 new cases of MM,and the percentage of T cell subsets in 40 of these patients were determined by flow cytometry.The clinical data of patients were reviewed,obtaining overall survival(OS)by follow-up,CD200 expression and prognosis of patients was analyzed by Kaplan-Meier and Cox proportional hazard regression.Results:CD200 was expressed in 51 cases(71.8%)and not in 20 cases(28.2%)from 71 MM patients.The percentage of CD4^(+) T cells and CD4/CD8 in CD200^(+) patients were lower than those in CD200^(-) patients(P<0.05).The median overall survival(OS)of CD200^(-) MM patients was 26.0(95%CI 18.7~33.2)months,the median OS of CD200^(+) patients was not reached(χ^(2)=4.210,P=0.040).The one-year,2-year OS for CD200^(+) MM was 54.2%and 54.2%,while one-year,2-year OS for CD200^(-) MM was 87.2%and 64.4%respectively.Cox risk regression model analysis showed that age≥65 years(HR=4.145,95%CI 1.252~13.728,P=0.020),CD200 positive(HR=2.617,95%CI 1.044~6.561,P=0.040)were independent risk prognostic factors.Conclusion:CD200 expression is heterogeneous,positive expression is a risk prognostic factor of OS in MM patients.

关 键 词：多发性骨髓瘤 CD200 预后 

分 类 号：R733.3[医药卫生—肿瘤]