桃核承气汤联合甘露醇治疗高血压性脑出血急性期脑水肿患者的效果  

Effects of Taohe Chengqi decoction combined with Mannitol in treatment of acute cerebral edema in patients with hypertensive intracerebral hemorrhage

作　　者：董荣蓉 DONG Rongrong(Department of Internal Medicine of Kaiyuan Traditional Chinese Medicine Hospital,Tieling 112300 Liaoning,China)

机构地区：[1]辽宁省开原市中医医院内科,辽宁铁岭112300

出　　处：《中国民康医学》2021年第21期71-73,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察桃核承气汤联合甘露醇治疗高血压性脑出血急性期脑水肿患者的效果。方法:选取62例高血压性脑出血急性期脑水肿患者为研究对象,按照随机数字表法分为对照组和观察组各31例。对照组给予甘露醇治疗,观察组在对照组基础上给予桃核承气汤治疗,比较两组治疗前后脑血流动力学指标[平均血流速度(Vm)、搏动指数(PI)、阻抗指数(RI)]水平、炎性因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平、疗效和并发症发生率。结果:治疗后,两组Vm、PI水平均高于治疗前,且观察组高于对照组,两组RI、CRP、TNF-α、IL-6水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为96.77%,高于对照组的70.97%,差异有统计学意义(P<0.05);观察组并发症发生率为19.35%,与对照组的16.13%比较,差异无统计学意义(P>0.05)。结论:桃核承气汤联合甘露醇治疗高血压性脑出血急性期脑水肿患者可提高治疗总有效率,改善脑血流动力学指标水平,以及降低炎性因子水平,优于单纯甘露醇治疗效果。Objective:To observe effects of Taohe Chengqi decoction combined with Mannitol in treatment of acute cerebral edema in patients with hypertensive intracerebral hemorrhage.Methods:62 acute cerebral edema patients with hypertensive intracerebral hemorrhage were selected as the research objects,and were divided into control group and observation group according to the random number table method,31 cases in each.The control group was treated with Mannitol,while the observation group was treated with Taohe Chengqi decoction on the basis of that of the control group.The levels of cerebral hemodynamic indexes[mean blood flow velocity(Vm),pulsatility index(PI),resistance index(RI)],the levels of the inflammatory factor indexes[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],the efficacy and the complication rate were compared between the two groups.Results:After the treatment,the levels of Vm and PI in the two groups were higher than those before the treatment,and those of the observation group were higher than those of the control group;the levels of RI,CRP,TNF-α,and IL-6 in the two groups were lower than those before the treatment,and those of the observation group were lower than those of the control group;and the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was 96.77%,which was higher than 70.97%in the control group,and the difference was statistically significant(P<0.05).Further,the incidence of complications in the observation group was 19.35%,compared with 16.13%in the control group,the difference was not statistically significant(P>0.05).Conclusions:Taohe Chengqi decoction combined with Mannitol in the treatment of acute cerebral edema in patients with hypertensive intracerebral hemorrhage can increase the total effective rate of treatment,improve the levels of cerebral hemodynamic indicators,and reduce the levels of inflammatory factors.Moreover,it is superior to single Mannitol.

关 键 词：桃核承气汤 甘露醇 高血压性脑出血 急性期脑水肿 脑血流动力学 炎性因子 

分 类 号：R743.34[医药卫生—神经病学与精神病学]