甲状腺乳头状癌彩超血流参数及临床病理与颈部淋巴结转移的关系  

Relationship Between Blood Flow Parameters of Color Doppler Ultrasound,Clinicopathology and Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma

作　　者：闫雪 段宇龙[1] 徐建林[1] 任海涛 智艳芳[3] YAN Xue;DUAN Yulong;XU Jianlin(Armed Police Corps Hospital of Henan,Zhengzhou,450052)

机构地区：[1]武警河南总队医院,450052 [2]河南(郑州)中汇心血管病医院,450052 [3]郑州大学第三附属医院,450052

出　　处：《实用癌症杂志》2021年第11期1795-1798,共4页The Practical Journal of Cancer

基　　金：河南省医学科技攻关计划(联合共建)项目(编号:LHGJ20190392)。

摘　　要：目的探讨甲状腺乳头状癌彩色多普勒超声(彩超)血流参数及临床病理与颈部淋巴结转移的关系。方法选择130例甲状腺乳头状癌患者作为研究对象,根据颈部淋巴结是否出现转移分为转移组49例、非转移组81例,分别对2组患者术前彩超血流参数与术后病理结果进行记录,分析彩超血流参数、临床病理参数与颈部淋巴结转移的关系。结果单因素和多因素Logisitic回归分析发现病灶数量>1个,被膜侵犯、合并桥本甲状腺炎是颈部淋巴结转移的独立危险因素(P<0.05)。转移组甲状腺乳头状癌患者彩超收缩期血流峰值速度(PSV)、脉动指数(PI)和阻力指数(RI)均显著高于非转移组(P<0.05),2组彩超收缩期加速时间(AT)水平比较未见显著差异(P>0.05)。彩超血流参数中PSV、PI和RI与甲状腺乳头状癌患者颈部淋巴结转移均呈显著正相关(P<0.05)。结论病灶数量>1个,被膜侵犯、合并桥本甲状腺炎是甲状腺乳头状癌颈部淋巴结转移的独立危险因素,彩超血流参数有助于在术前预测患者颈部淋巴结的转移情况,对临床确定治疗方案有参考价值。Objective To explore the relationship between blood flow parameters of color Doppler ultrasound(CDUS),clinicopathology and cervical lymph node metastasis in papillary thyroid carcinoma.Methods A total of 130 patients with papillary thyroid carcinoma,according to presence or absence of cervical lymph node metastasis,were divided into metastasis group(49 cases)and non-metastasis group(81 cases).The preoperative CDUS blood flow parameters and postoperative pathological results in both groups were recorded.The relationship between CDUS blood flow parameters,clinicopathological parameters and cervical lymph node metastasis was analyzed.Results It was found by univariate and multivariate logisitic regression analysis that number of lesions more than 1,capsule invasion and Hashimoto's thyroiditis were independent risk factors of cervical lymph node metastasis(P<0.05).The peak systolic velocity(PSV),pulsatility index(PI)and resistance index(RI)in metastasis group were significantly higher than those in non-metastasis group(P<0.05).There was no significant difference in acceleration time(AT)between the 2 groups(P>0.05).PSV,PI and RI in CDUS blood flow parameters were significantly positively correlated with cervical lymph node metastasis in patients with papillary thyroid carcinoma(P<0.05).Conclusion The number of lesions>1,capsule invasion and Hashimoto's thyroiditis are independent risk factors of papillary thyroid carcinoma cervical lymph node metastasis.CDUS blood flow parameters are beneficial to predict lateral cervical lymph node metastasis before surgery,which are of reference value in clinically determining treatment plans.

关 键 词：甲状腺乳头状癌 颈部淋巴结转移 血流参数 彩色多普勒超声 临床病理 

分 类 号：R736.1[医药卫生—肿瘤]