早期食管癌患者行内镜黏膜下剥离术术后并发狭窄的相关危险因素分析  

Analysis of Related Risk Factors of Complicated Stenosis After Endoscopic Submucosal Dissection in Patients with Early Esophageal Carcinoma

作　　者：郑荣[1] 王冬梅[1] 张英[1] ZHENG Rong;WANG Dongmei;ZHANG Ying(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第一附属医院,450000

出　　处：《实用癌症杂志》2021年第11期1831-1833,共3页The Practical Journal of Cancer

基　　金：河南省科技攻关计划(编号:102102310320)。

摘　　要：目的分析早期食管癌患者行内镜黏膜下剥离术(ESD)治疗术后并发再狭窄的相关危险因素。方法选择146例早期食管癌患者作为研究对象,按照是否发生狭窄分为观察组(发生狭窄)和对照组(未发生狭窄),所有患者均行ESD。收集患者年龄、性别、术后病理学类型、病灶位置、病灶纵向长径、组织浸润深度等临床资料,分析ESD后狭窄的相关危险因素。结果2组性别、年龄、病灶位置比较,差异无统计学意义(P>0.05);2组病灶纵向长径、病理学类型、组织浸润深度及术后创面>3/4食管周径比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,病灶纵向长径≥50 mm、组织浸润深度(m3+sm1)及术后创面>3/4食管周径均是造成狭窄的独立危险因素。结论病灶纵向长径≥50 mm、组织浸润深度(m3+sm1)及术后创面>3/4食管周径是ESD治疗早期食管癌患者术后并发狭窄的相关危险因素。对于此类患者应加强术后随访,做好预防措施,最大程度降低术后狭窄发生率。Objective To analyze the risk factors of postoperative restenosis after endoscopic submucosal dissection(ESD)in patients with early esophageal cancer.Methods 146 patients with early esophageal cancer,according to the occurrence of stenosis,were divided into the observation group(stenosis)and the control group(no stenosis),All patients were ESD,To collect the clinical data of age,sex,pathological type,location,longitudinal length,depth of tissue invasion,Analyze the risk factors of post ESD stenosis.Results Comparison of sex,age and location of lesions between the 2 groups,(b)The difference was not statistically significant(P>0.05);Comparison of longitudinal length,pathological type,depth of tissue invasion and 3/4 esophageal circumference>postoperative wound between the 2 groups,difference was statistically significant(P<0.05).A multivariate logistic regression analysis showed,The longitudinal diameter≥50 mm、tissue infiltration depth(m3sm1)and 3/4 esophageal circumference were independent risk factors for stenosis.Conclusion Longitudinal≥50 mm、depth of tissue invasion(m3sm1)and 3/4 perigesophageal diameter of postoperative wound are the risk factors for postoperative stenosis in ESD patients with early esophageal cancer,Follow-up should be enhanced for such patients,Take precautions,To minimize the incidence of postoperative stenosis.

关 键 词：早期食管癌 内镜黏膜下剥离术 食管狭窄 危险因素 

分 类 号：R735.1[医药卫生—肿瘤]