蝎毒多肽的抗肿瘤作用机制  

Antitumor Mechanism of Scorpion Venom Polypeptides

作　　者：范红波[1] 黄欣媛[2] Fan Hongbo;Huang Xinyuan(Department of Basic Medicine,Hubei Polytechnic Institute,Xiaogan,Hubei 432000,China;School of Life Science and Technology,Hubei Engineering University,Xiaogan,Hubei 432000,China)

机构地区：[1]湖北职业技术学院医学基础部,湖北孝感432000 [2]湖北工程学院生命科学技术学院,湖北孝感432000

出　　处：《湖北工程学院学报》2021年第6期42-46,共5页Journal of Hubei Engineering University

基　　金：湖北省教育厅科研项目(B2018459,Q20172704);湖北职业技术学院科研项目(2017B02)。

摘　　要：蝎毒的主要生理活性组分是其内含的多种生物活性多肽,一般长度为20~80氨基酸,分子内含2~4个二硫键,理化性质稳定并能发挥多种药理作用。蝎毒多肽是离子通道抑制剂,而离子通道在癌细胞中失调和过表达,在肿瘤的发展和侵袭中起重要作用。因此,蝎毒多肽具有明显的抗肿瘤效用,其作用机制主要有诱导癌细胞凋亡,抑制癌细胞增殖、侵袭、转移和血管生成,以及调节免疫细胞活性。The main physiologically active component of scorpion venom is a variety of bioactive peptides,generally 20~80 amino acids in length,with 2~4 disulfide bonds in the molecule.It has stable physical and chemical properties and can exert a variety of pharmacological effects.Studies have shown that ion channels are dysregulated and over-expressed in cancer cells,playing important roles in tumor development and invasion.Scorpion venom polypeptides are ion channel inhibitors and therefore have demonstrable antitumor activity.The antitumor mechanisms of scorpion venom polypeptides mainly intend to induce cancer cell apoptosis,inhibit cancer cell proliferation,invasion,metastasis,and angiogenesis and modulate immune cell activity.

关 键 词：蝎毒多肽 抗肿瘤 离子通道 作用机制 

分 类 号：Q89[生物学]