培元抗癌汤治疗大肠癌术后化疗临床研究  

Clinical Study on Peiyuan Kang’ai Tang for Postoperative Chemotherapy of Colorectal Cancer

作　　者：尹鑫 YIN Xin

机构地区：[1]杭州市中医院肛肠科,浙江杭州310000

出　　处：《新中医》2021年第21期162-166,共5页New Chinese Medicine

摘　　要：目的:观察培元抗癌汤治疗大肠癌术后化疗患者的临床疗效及对血管内皮生长因子(VEGF)、免疫功能的影响。方法:选取80例行大肠癌根治术后接受化疗的患者,以简单随机化法分为对照组与治疗组各40例。对照组采取奥沙利铂;亚叶酸钙;5-氟尿嘧啶(FOLFOX4)化疗,治疗组在对照组基础上给予培元抗癌汤治疗。比较2组临床疗效、不良反应及治疗前后血清肿瘤因子水平、免疫功能。结果:治疗组治疗总有效率85.00%,高于对照组65.00%(P<0.05)。与同组治疗前比较,治疗后2组VEGF、血清癌胚抗原(CEA)、糖类抗原199(CA199)水平均降低(P<0.05);与对照组治疗后比较,治疗组治疗后VEGF、CEA、CA199水平均较低(P<0.05)。与同组治疗前比较,治疗组治疗后CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平升高(P<0.05),CD8^(+)水平降低(P<0.05);对照组治疗后CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平降低(P<0.05),CD8^(+)水平升高(P<0.05)。治疗组不良反应发生率20.00%,低于对照组42.50%(P<0.05)。结论:针对大肠癌术后化疗患者给予培元抗癌汤治疗疗效显著,可抑制肿瘤新生血管再生,降低肿瘤标志物水平,提高机体免疫力,减少药物不良反应的发生。Objective:To observe the clinical effect of Peiyuan Kang’ai tang for patients with postoperative chemotherapy of colorectal cancer and its effect on vascular endothelial growth factor(VEGF)and immune function.Methods:A total of80 cases of patients receiving chemotherapy after radical resection of colorectal cancer were selected and divided into the control group and the treatment group according to the simple randomization method,40 cases in each group.The control group was given chemotherapy with oxaliplatin,calcium leucovorin and 5-fluorouracil(FOLFOX4),and the treatment group was additionally treated with Peiyuan Kang’ai tang based on the treatment of the control group.The levels of serum tumor factors and immune function before and after treatment,clinical effects and adverse reactions in the two groups were compared.Results:The total effective rate was 85.00%in the treatment group,higher than that of 65.00%in the control group(P<0.05).After treatment,the levels of VEGF,serum carcinoembryonic antigen(CEA)and carbohydrate antigen 199(CA199)in the two groups were decreased when compared with those before treatment(P<0.05);the levels of VEGF,CEA and CA199 in the treatment group were lower than those in the control group(P<0.05).After treatment,the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the treatment group were increased when compared with those before treatment(P<0.05),and the level of CD8^(+)was decreased(P<0.05);the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the control group were decreased when compared with those before treatment(P<0.05),and the level of CD8^(+)was increased(P<0.05).The incidence of adverse reactions was 20.00%in the treatment group,lower than that of 42.50%in the control group(P<0.05).Conclusion:The application of Peiyuan Kang’ai tang has a significant curative effect in treating patients with postoperative chemotherapy of colorectal cancer,which can inhibit the regeneration of tumor angiogenesis,decrease the levels of tumor markers,improve body immunity,and reduce the inc

关 键 词：大肠癌 术后 培元抗癌汤 化疗 血管内皮生长因子 免疫功能 

分 类 号：R735.34[医药卫生—肿瘤]