急性缺血性脑卒中患者脑组织微循环的磁共振灌注加权成像特点  

Magnetic resonance perfusion-weighted imaging signatures of cerebral microcirculation in patients with acute ischemic stroke

作　　者：李兆妍 张晓曼[2] 曹心慧[2] 王军杰[2] 邰剑青[3] LI Zhao-yan;ZHANG Xiao-man;CAO Xin-hui;WANG Jun-jie;TAI Jian-qing(Department of Encephalopathy,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;Department of Neurology,Zhengzhou First People′s Hospital,Zhengzhou 450000,China;Department of Radiology,Zhengzhou First People′s Hospital,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一附属医院脑病科,郑州市450000 [2]河南省郑州市第一人民医院神经内科,郑州市450000 [3]河南省郑州市第一人民医院影像科,郑州市450000

出　　处：《广西医学》2021年第18期2154-2156,共3页Guangxi Medical Journal

基　　金：河南省自然科学基金(162300410045)。

摘　　要：目的探讨急性缺血性脑卒中(AIS)患者脑组织微循环的磁共振灌注加权成像(MR-PWI)特点。方法对74例AIS患者进行MR-PWI检查,记录局部脑血流量(rCBF)、局部脑血容量(rCBV)、平均通过时间(MTT)和达峰值时间(TTP)。分析AIS患者MR-PWI各参数的异常情况和脑组织微循环的特点。结果AIS患者MR-PWI各参数异常率从高至低分别为TTP、MTT、rCBF、rCBV。74例患者中有3例为过度灌注,其余71例患者中有22例为缺血期(30.99%)、2例为代偿期(2.82%)、18例为失代偿期(25.35%)、29例为梗死期(40.85%)。结论MR-PWI检查中TTP比较敏感,临床上可以根据MR-PWI判断AIS患者不同时期的脑组织损伤程度,实现个体化评估,指导临床精准治疗。Objective To explore the magnetic resonance perfusion-weighted imaging(MR-PWI) signatures of cerebral microcirculation in patients with acute ischemic stroke(AIS).Methods Seventy-four AIS patients underwent MR-PWI examination to record their regional cerebral blood flow(rCBF),regional cerebral blood volume(rCBV),mean transit time(MTT),and time to peak(TTP).The abnormality of various parameters of MR-PWI and the characteristics of cerebral microcirculation were analyzed in AIS patients.Results Among AIS patients,the abnormal rates of various parameters of MR-PWI decreased in the sequence of TTP,MTT,rCBF,and rCBV.Among the 74 patients,three cases had hyperperfusion,and the remaining 71 cases included 22(30.99%) cases in the ischemia stage,two(2.82%) cases in the compensatory stage,18(25.35%) cases in the decompensated stage,and 29(40.85%) cases in the infarction stage.Conclusion TTP is more sensitive in MR-PWI examination,clinically,the severity of brain tissue injury in different stages can be identified in AIS patients based on MR-PWI,thus achieving individualized evaluation and guiding clinical precise treatment.

关 键 词：急性缺血性脑卒中 磁共振灌注加权成像 脑灌注 

分 类 号：R743.3[医药卫生—神经病学与精神病学]