双环化反应构建吡咯衍生物的合成方法概述  

Overview of the Synthetic Methods for Constructing Pyrroles by Bicyclization

作　　者：范威 Fan Wei(Office of Research Affairs,Chuzhou City Vocation College,Chuzhou,Anhui 239000,China)

机构地区：[1]滁州城市职业学院科研处,安徽滁州239000

出　　处：《伊犁师范学院学报（自然科学版）》2021年第3期38-44,共7页Journal of Yili Normal University：Natural Science Edition

基　　金：安徽省教育厅科研项目(KJ2020A1003);安徽省教育厅教研项目(2020jyxm1315).

摘　　要：吡咯是常见且重要的五元氮杂环,该骨架存在于Elacomine、Tilivalline、Goniothalactam等活性分子中.该类衍生物可用作RSK抑制剂、Mcl-1抑制剂、降压药等,具有非常广泛的用途.通过双环化反应可以合成各种吡咯衍生物,综述了利用双环化反应构建三元、四元、五元、六元并吡咯衍生物的合成方法及反应机理,以期为进一步拓展双环化反应的应用提供借鉴.Pyrrole is a common and important five-membered nitrogen heterocycle,this skeleton exists in active molecules such as Elacomine,Tilivalline,Goniothalactam.Such derivatives can be used as RSK inhibitors,Mcl-1 inhibitors,antihypertensive drugs,which have a very wide range of uses.Various pyrroles can be synthesized through bicyclization reaction.This article reviews the synthesis methods and reaction mechanisms of three-,four-,five-and six-membered pyrroles using bicyclization reactions,in order to provide a reference for further expanding the application of bicyclization reactions.

关 键 词：吡咯衍生物 双环化 五元氮杂环 反应机理 

分 类 号：O626[理学—有机化学]