多效生长因子介导神经元修复作用的研究进展  

Research Progress of Pleiotrophin-mediated Neuron Repair Effects

作　　者：席文华 刘文勋[1,2] 海克蓉[2] 叶青山[2] XI Wenhua;LIU Wenxun;HAI Kerong;YE Qingshan(Ningxia Medical University,Yinchuan 750004,China;Department of Anesthesiology,People′s Hospital of Ningxia Hui Autonomous Region,Yinchuan 750002,China)

机构地区：[1]宁夏医科大学,银川750004 [2]宁夏回族自治区人民医院麻醉科,银川750002

出　　处：《医学综述》2021年第22期4379-4385,共7页Medical Recapitulate

基　　金：国家自然科学基金(81760339)。

摘　　要：中枢神经元损伤后再生是目前神经功能修复中的难点问题。在神经功能修复过程中多效生长因子(PTN)起重要作用,其可通过诱导和激活自身处于休眠和抑制状态的神经元分化、增殖,促进神经细胞功能修复。因此,明确PTN在神经元轴突和树突中的修复作用、促轴突再生作用、神经元保护作用以及在新生神经元中的调节作用,可以为临床相关疾病的治疗提供新思路。此外,深入研究PTN信号通路中各分子促进神经元修复的机制,对脑保护具有重要意义。The regeneration of central neurons after injury is a difficult problem in the repair of neural function.Pleiotrophin(PTN)plays an important role in the process of neural functional repair,which can promote the functional repair of nerve cells by inducing and activating the differentiation and proliferation of dormant and inhibitory neurons.Therefore,to clarify the role of PTN in neuronal axon and dendritic repair,axonal regeneration promotion,neuronal protection and newborn neurons regulation can provide new ideas for the treatment of related clinical diseases.In addition,in-depth study of the mechanisms of various molecules in PTN signaling pathway promoting neuronal repair is of great significance for brain protection.

关 键 词：神经元修复 多效生长因子 神经保护 信号通路 

分 类 号：R741.02[医药卫生—神经病学与精神病学]