子宫内膜透明细胞癌的诊断及分子分型  

Diagnosis and Molecular Typing of Endometrial Clear Cell Carcinoma

作　　者：杨亚男 冯阿婷 董卫红 YANG Yanan;FENG Ating;DONG Weihong(Department of Obstetrics and Gynecology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院妇产科,武汉430022

出　　处：《医学综述》2021年第21期4245-4251,共7页Medical Recapitulate

摘　　要：子宫内膜透明细胞癌(ECCC)是一种较罕见的子宫内膜癌,侵袭性强,预后较差,诊断主要基于肿瘤的形态学及分子生物学特征。然而其组织形态学表现多样,观察者之间诊断的一致性差。ECCC是一种异质性的肿瘤,目前传统的组织学分类法在指导个体化治疗、评估疗效及预测预后等方面的局限性日益突显。近年来,基于肿瘤细胞分子特征的分子分型有了一定进展,分子分型的完善将有助于提高ECCC诊断的可重复性,对精准诊疗及预测患者预后具有重要的指导意义。Endometrial clear cell carcinoma(ECCC)is a relatively rare type of endometrial carcinoma with strong invasiveness and poor prognosis.Its diagnosis is mainly based on the morphological and molecular biological characteristics of the tumor.However,the histomorphological manifestations are varied and the diagnosis consistency among the observers is poor.ECCC is a heterogeneous disease.The limitation of traditional histological classification in guiding individual treatment,evaluating the curative effect,and predicting prognosis has become increasingly prominent.In recent years,a certain progress has been made in molecular typing based on the molecular characteristics of tumor cells,which will help improve the repeatability of the diagnosis of ECCC and has great guiding significance for the accurate diagnosis and prognosis prediction.

关 键 词：子宫内膜透明细胞癌 精准治疗 分子分型 

分 类 号：R737.33[医药卫生—肿瘤]