基于^(1)H-NMR技术的2型糖尿病代谢组学研究进展  

Research Progress of Type 2 Diabetes Mellitus Based on ^(1)H-NMR Technology

作　　者：郑芳萍 高碧珍[2] 陈学勤[1,3] ZHENG Fangping;GAO Bizhen;CHEN Xueqin(Department of Endocrinology,Xiamen Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine,Xiamen 361001,China;Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;Department of Traditional Chinese Medicine,the First Affiliated Hospital of Xiamen University,Xiamen 361003,China)

机构地区：[1]福建中医药大学附属厦门中医院内分泌科,福建厦门361001 [2]福建中医药大学,福州350122 [3]厦门大学附属第一医院中医科,福建厦门361003

出　　处：《医学综述》2021年第21期4305-4309,共5页Medical Recapitulate

基　　金：福建省第五轮卫生教育联合攻关计划项目(2019-WJ-39)。

摘　　要：2型糖尿病(T2DM)的发生发展与体内多种代谢紊乱有关,但目前尚无特定的指标可以反映体内动态复杂的代谢变化,探索新的生物标志物有助于更好地了解T2DM发病机制的生物学基础。代谢组学可以反映小分子代谢物在疾病发生发展及治疗过程中变化的整体水平,可用于探索疾病生理病理变化和监测药物疗效。近年来,核磁共振氢谱(^(1)H-NMR)技术在T2DM及其并发症和中医药治疗的代谢组学研究方面展现出良好的应用前景。未来,^(1)H-NMR技术可能成为预测T2DM发生发展、开发新药或精准药物治疗监测的有力工具。The occurrence and development of type 2 diabetes mellitus(T2DM)is related to a variety of metabolic disorders in vivo,but there is no specific indicator that can reflect the dynamic and complex metabolic changes in the body,and the exploration of new biomarkers helps to better understand the biological basis of the pathogenesis of T2DM.Metabonomics can reflect the overall level of changes in small molecule metabolites during the occurrence,development and treatment of diseases,and can be used to explore the physiological and pathological changes of diseases and monitor drug efficacy.In recent years,nuclear magnetic resonance hydrogen spectroscopy(^(1)H-NMR)technology has shown promising application prospects in the metabonomics study of T2DM and its complications and treatment of traditional Chinese medicine.In the future,^(1)H-NMR technology may become a powerful tool to predict the occurrence and development of T2DM,develop new drugs or realize monitoring of the precise medication.

关 键 词：2型糖尿病 核磁共振氢谱 代谢组学 中医药治疗 

分 类 号：R587.1[医药卫生—内分泌] R392.11[医药卫生—内科学]