人乳头瘤病毒多重感染特点及其与宫颈病变的关系  

Characteristics of multiple infection of human papillomavirus and its relationship with cervical lesions

作　　者：王梓慈 陈晓静 陈金娇 范良生[1] 王薇[1] 肖海群 WANG Zici;CHEN Xiaojing;CHEN Jinjiao;FAN Liangsheng;WANG Wei;XIAO Haiqun(Department of Obstetrics and Gynecology,the First Affiliated Hospital of Guangzhou Medical University,Guangdong Province,Guangzhou,510120,China)

机构地区：[1]广州医科大学附属第一医院妇产科,广东广州510120

出　　处：《中国医药导报》2021年第33期99-101,106,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81672589、81971341)。

摘　　要：目的了解人乳头瘤病毒(HPV)多重感染的特点及其与宫颈病变的关系,为宫颈疾病的筛查、治疗和疫苗研发提供参考。方法回顾分析2014年1月至2020年1月广州医科大学附属第一医院就诊并有宫颈病理结果的1175例患者的临床资料。按不同病理诊断,分为宫颈炎组(107例)、宫颈上皮内瘤变(CIN)Ⅰ组(364例)、CINⅡ~Ⅲ组(447例)、宫颈癌组(257例)。比较不同病理分型患者的HPV多重感染病例数、年龄分布特点、感染型别及形式特点。结果HPV多重感染291例,多重感染率为24.77%。不同病理分型多重感染发生率比较,差异有统计学意义(P<0.05)。30岁以下人群HPV多重感染以CINⅠ型为主,30岁以后人群的HPV多重感染则均以CINⅡ~Ⅲ为主。HPV型别检出率最高的前3种亚型均属高危型,分别为HPV16、52和58。不同宫颈病变中,以高危HPV混合其他型别感染为主,并且二重感染的比例最高。结论HPV多重感染与CIN进展相关,对于30岁以下人群及合并HPV16、52、58型多重感染的患者应重点防治。Objective To investigate the characteristics of multiple infection of human papillomavirus(HPV)and its relationship with cervical lesions,which can provide references for the screening,treatment and vaccine development of cervical diseases.Methods The clinical data of 1175 patients with cervical pathology in the First Affiliated Hospital of Guangzhou Medical University from January 2014 to January 2020 were retrospectively analyzed.According to the different pathological diagnosis,they were divided into cervicitis group(107 cases),cervical intraepithelial neoplasia(CIN)Ⅰgroup(364 cases),CINⅡ-Ⅲgroup(447 cases)and cervical cancer group(257 cases).The number of multiple infection of HPV cases,age distribution characteristics,infection type,and characteristics form of patients with different pathological types were compared.Results There were 291 cases of multiple infection of HPV,and the multiple infection rate was 24.77%.There were statistical differences in the incidence of multiple infection among different pathological types(P<0.05).CINⅠwas the predominant type of multiple infection of HPV in people under 30 years old,and CINⅡ-Ⅲwas the predominant multiple infection of HPV in people after 30 years old.The highest HPV type detection rate of the first three kinds of subtypes were high-risk,respectively,HPV16,52 and 58.Different cervical lesions were dominated by high-risk HPV mixed with other types of infection,and the proportion of double infection was the highest.Conclusion Multiple infection of HPV are found to be associated with the progression of cervical intraepithelial neoplasia,the prevention and treatment should be focused on patients under 30 years of age and patients with multiple HPV infections of HPV16,52 and 58.

关 键 词：多重感染 人乳头瘤病毒 宫颈上皮内瘤变 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]