卵巢上皮性癌患者血清CA125变化与预后的关系  

Relationship between serum CA125 level and prognsis in patients with epithelial ovarian carcinoma

作　　者：徐林[1] 刁海丹[1] XU Lin;DIAO Hai-dan(Department of Gynecology,the Third People′s Hospital of Dalian City,Liaoning Province,Dalian,116033,China)

机构地区：[1]大连市第三人民医院妇科,辽宁大连116033

出　　处：《中国当代医药》2021年第33期30-34,共5页China Modern Medicine

摘　　要：目的探讨卵巢上皮性癌患者治疗过程中血清糖类抗原125(CA125)水平及其动态变化与预后的关系,为临床寻找简便、可靠的预后预测指标。方法回顾性分析2017年1月至2019年12月大连市第三人民医院收治的66例卵巢上皮性癌患者的临床资料,研究术前血清CA125水平、术后1程化疗后血清CA125下降率、2程化疗后血清CA125是否降至正常值以及CA125半衰期(t1/2)对复发的影响。结果按照患者术前的CA125水平,将其分为CA125≤500 U/ml组、CA125>500~1000 U/ml组和CA125>1000 U/ml组,三组的复发率比较,差异无统计学意义(P>0.05)。按照患者的1程化疗后CA125的下降率,将其分为CA125下降率≤70%组、CA125下降率70%~90%组和CA125下降率>90%组。CA125下降率≤70%组的复发率高于CA125下降率70%~90%组和CA125下降率>90%组,差异有统计学意义(P<0.05)。按照2程化疗后血清CA125是否降至35 U/ml,将其分为CA125≤35 U/ml组和CA125>35 U/ml组。结果显示,CA125>35 U/ml组的复发率高于CA125≤35 U/ml组,差异有统计学意义(P<0.05)。按照公式计算各患者治疗过程中CA125t1/2,将其分为t1/2≤20 d组和t1/2>20 d组,结果显示,t1/2>20 d组的复发率高于t1/2≤20 d组,复发中位时间短于t1/2≤20 d组,差异均有统计学意义(P<0.05)。结论术后1程化疗后CA125下降率,术后2程化疗后CA125是否降至正常以及CA125的t1/2与卵巢上皮性癌患者的预后相关,有可能成为评估预后和预测复发的有效指标。Objective By investigating the prognostic value of serum carbohydrate antigen 125(CA125)level change in patients with epithelial ovarian carcinoma,find the simple and reliable prognostic indicators.Methods Collected and retrospectively analyzed the clinical dates of 66 patients with epithelial ovarian carcinoma who were treated in the the Third People′s Hospital of Dalian from January 2017 to December 2019.Researched the relationships between preoperative serum CA125 level and recurrence,the rate of descent after one cycle of postoperative chemotherapy and recurrence,whether the serum CA125 level was normal after two cycles of postoperative chemotherapy and recurrence,the half-life(t1/2)of CA125 and recurrence.Results According to the level of preoperative serum CA125,patients were divided into CA125≤500 U/ml group,CA125>500-1000 U/ml group and CA125>1000 U/ml group.There was no significant difference in recurrence rate among the three groups(P>0.05).According to the rate of descent after one cycle of postoperative chemotherapy,patients were divided into CA125 reduction rate≤70%group,CA125 reduction rate 70%-90%group and CA125 reduction rate>90%group.The recurrence rate of the group with CA125 reduction rate≤70%group was higher than the group with CA125 reduction rate 70%-90%group and CA125 reduction rate>90%group,and the difference was statistically significant(P<0.05).According to whether serum CA125 decreased to 35 U/ml after the second course of chemotherapy,the patients were divided into CA125≤35 U/ml group and CA125>35 U/ml group.The results showed that the recurrence rate of CA125>35 U/ml group was higher than that of CA125≤35 U/ml group,the difference was statistically significant(P<0.05).According to the t1/2 of CA125,patients were divided into t1/2≤20 d group and t1/2>20 d group.The results showed that the recurrence rate of t1/2>20 d group was higher than that of t1/2≤20 d group,and the median time of recurrence was shorter than that of t1/2≤20 d group,the differences were statistical

关 键 词：卵巢上皮性癌 糖类抗原125 预后 复发 

分 类 号：R737[医药卫生—肿瘤]