萎缩性舌炎分型与外周血维生素B12、叶酸、血细胞参数变化的相关性  

The correlation between the classification of atrophic glossitis and changes of vitamin B12,folic acid and blood cell parameters

作　　者：宋月凤 王文梅[1] 徐冬梅 王翔[1] 李兵[2] 赵毛毛 段宁[1] SONG Yuefeng;WANG Wenmei;XU Dongmei;WANG Xiang;LI Bing;ZHAO Maomao;DUAN Ning(Department of Oral Mucosal Diseases,Nanjing Stomatological Hospital,Medical School of Nanjing University,Nanjing 210008,China;Department of Clinical Laboratory,Nanjing Stomatological Hospital,Medical School of Nanjing University,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属口腔医院,南京市口腔医院口腔黏膜病科,江苏南京210008 [2]南京大学医学院附属口腔医院,南京市口腔医院检验科,江苏南京210008

出　　处：《口腔疾病防治》2022年第3期185-190,共6页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：国家自然科学基金项目(81870767)。

摘　　要：目的探讨萎缩性舌炎(atrophic glossitis,AG)分型及其与维生素B12(vitamin B12,VitB12)、叶酸(fo⁃lic acid,FOL)及血细胞参数变化的相关性。方法70例AG患者(AG组)按照是否伴有舌黏膜糜烂或溃疡分为复杂型AG组和单纯型AG组,65例无口腔黏膜病的志愿者为对照组,检测复杂型AG组、单纯型AG组及对照组外周血的VitB12、FOL及血细胞参数水平,采用SPSS 25.0统计软件对数据进行统计学分析。结果复杂型AG组VitB12水平低于单纯型AG组,且红细胞计数(red bloodcellcount,RBC)为(3.52±0.69)×10^(12)·L^(⁃1),血红蛋白(hemoglobin,HGB)为(11.97±1.70)g·dL^(⁃1),白细胞计数(white bloodcellcount,WBC)为(4.85±1.16)×10^(9)·L^(⁃1),中性粒细胞计数(neutrophil count,NEUT)为(2.76±0.99)×10^(9)·L^(⁃1),淋巴细胞计数(lymphocyte count,LYMPH)为(1.48±0.44)×10^(9)·L^(⁃1),以上结果均低于单纯型AG组(P<0.05);复杂型AG组平均红细胞体积(mean redbloodcellvolume,MCV)为(104.90±11.13)fL,平均血红蛋白含量(mean corpuscularhemoglobin,MCH)为(34.83±4.56)pg,平均血红蛋白浓度(mean corpuscularhemoglobinconcentration,MCHC)为(331.09±13.60)g·L^(⁃1),以上结果均高于单纯型AG组(P<0.05),FOL水平无统计学差异(P>0.05)。VitB12、MCV、MCH、MCHC、WBC、LYMPH、NEUT水平与萎缩性舌炎分型存在相关性(P<0.05)。结论复杂型AG的VitB12缺乏程度更明显,大细胞性贫血情况尤为突出,且与WBC、NEUT、LYMPH水平具有相关性。Objective To investigate the classification of atrophic glossitis and to study the correlation between the classification and changes of VitB12,folic acid(FOL)and blood cell parameters.Methods A total of 70 patients with atrophic glossitis(AG)were divided into complex type and simple type according to whether they had ulcer or erosion on the tongue mucosa or not.Another 65 healthy subjects during the same period were collected as the control group.The levels of vitamin B12,FOL and blood cell parameters were statistically analyzed using SPSS 25.0 software package.Results The levels of vitamin B12,red blood cell count(RBC)(3.52±0.69)×10^(12)·L^(⁃1),hemoglobin(HGB)(11.97±1.70)g·dL^(⁃1),white blood cell count(WBC)(4.85±1.16)×10^(9)·L^(⁃1),neutrophil count(NEUT)(2.76±0.99)×10^(9)·L^(⁃1),lymphocyte count(LYMPH)(1.48±0.44)×10^(9)·L^(⁃1) in complex type AG group were lower than those in simple type AG group(P<0.05).The levels of mean red blood cell volume(MCV)(104.90±11.13)fL,mean corpuscular hemoglobin(MCH)(34.83±4.56)pg,mean corpuscular hemoglobin concentration(MCHC)(331.09±13.60)g·L^(⁃1) were higher than those in the simple type AG group(P<0.05).There was no significant difference in FOL content between these two groups(P>0.05).The levels of VitB12,MCV,MCH,MCHC,WBC,lymph and neut were correlated with the classifica⁃tion of atrophic glossitis(P<0.05).Conclusion VitB12 deficiency was more apparent in complex AG,especially in large cell anemia,which correlated with the levels of WBC,NEUT,and LYMPH.

关 键 词：萎缩性舌炎 分型 维生素B12 叶酸 血细胞参数 贫血 大细胞性贫血 溃疡 

分 类 号：R78[医药卫生—口腔医学]