Silver-catalyzed decarboxylative C-H functionalization of cyclic aldimines with aliphatic carboxylic acids  

作　　者：Jingjing Wang Xue Liu Ziyan Wu Feng Li Tingting Qin Siyuan Zhang Weiguang Kong Lantao Liu 

机构地区：[1]Henan Key Laboratory of Biomolecular Recognition and Sensing,College of Chemistry and Chemical Engineering,Shangqiu Normal University,Shangqiu 476000,China [2]College of Chemistry and Pharmaceutical Engineering,Nanyang Normal University,Nanyang 473061,China [3]College of Chemistry,Zhengzhou University,Zhengzhou 450052,China

出　　处：《Chinese Chemical Letters》2021年第9期2777-2781,共5页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.21402116,21502111,21572126);the Science and Technology Innovation Talents of Henan Province(No.2018JQ0011);the Key Science Research of Education Committee in Henan Province(No.21A150044)。

摘　　要：Silver-catalyzed decarboxylative C–H alkylation of cyclic aldimines with abundant aliphatic carboxylic acids has been realized under mild reaction conditions generating the corresponding products in moderate to good yields(32%–91%).In addition,a gram-scale reaction,late-stage modification of drug,synthetic transformation of the product,and further application of the catalytic strategy were also performed.Preliminary studies indicate that the reaction undergoes a radical process.

关 键 词：RADICAL DECARBOXYLATION C-H functionalization Cyclic aldimines Aliphatic carboxylic acids 

分 类 号：O621.251[理学—有机化学]