An intriguing electrochemical impedance aptasensor based on a porous organic framework supported silver nanoparticles for ultrasensitively detecting theophylline  

作　　者：Zhang-Ye Han Hong-Kai Li Qian-Qian Zhu Rongrong Yuan Hongming He 

机构地区：[1]Tianjin Key Laboratory of Structure and Performance for Functional Molecules,College of Chemistry,Tianjin Normal University,Tianjin 300387,China [2]Department of Materials Science and Engineering,Jilin Jianzhu University,Changchun 130118,China

出　　处：《Chinese Chemical Letters》2021年第9期2865-2868,共4页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(No.21801187)。

摘　　要：Porous organic frameworks(POFs)are excellently stable porous materials,which can be employed as host platforms to support metal nanoparticles as functional composites for various applications.Herein,a novel POF is successfully prepared via Friedel-Crafts reaction.Silver nanoparticles(AgNPs)are embedded in the prepared POF to generate an Ag@POF composite,which not only possesses high surface area,outstanding physicochemical stability and outstretchedπ-conjugation skeleton,but also exhibits preferable electrochemical stability and conductivity.This composite is able to immobilize a mass of aptamer strands to fabricate an intriguing electrochemical aptasensor.Electrochemical impedance spectroscopy(EIS)is a commonly used technology to analyze the electrochemical signal variation.The Ag@POF-based biosensor shows the excellent electrochemical detection behavior through analyzing EIS.For instance theophylline as a research mode,the Ag@POF based electrochemical aptasensor reveals ultra-sensitiveness,high selectivity,remarkable stability,good repeatability and simple operability even in various real samples.Notably,this aptasensor has the sensitive detection performance with the limit of detection of 0.191 pg/m L(1.06 pmol/L)in a wide concentration range of 5.0×10^(-4)–5.0 ng/m L(2.78×10^(-3)–27.8 nmol/L).

关 键 词：Ag@POF composite APTAMER Electrochemical aptasensor THEOPHYLLINE Sensitive detection 

分 类 号：R318[医药卫生—生物医学工程] TB383.1[医药卫生—基础医学] O657.1[一般工业技术—材料科学与工程]