丙戊酸钠缓释片对老年癫痫患者临床疗效与认知功能的影响  

Effect of compound sodium valproate and valproic acid sustained release tablets on clinical efficacy and cognitive function in elderly patients with epilepsy

作　　者：曹晖 CAO Hui(Department Four of Brain,Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110034,China)

机构地区：[1]辽宁中医药大学附属医院第二医院脑四科,110034

出　　处：《中国实用医药》2021年第32期142-145,共4页China Practical Medicine

摘　　要：目的探讨丙戊酸钠缓释片对老年癫痫患者临床疗效与认知功能的影响。方法104例老年癫痫患者,随机分为对照组及观察组,每组52例。对照组使用卡马西平片治疗,观察组使用丙戊酸钠缓释片治疗。比较两组患者的临床疗效,治疗前后的各项血清指标[γ-氨基丁酸(GABA)、谷氨酸(Glu)、神经元特异性烯醇化酶(NSE)、超氧化物歧化酶(SOD)、脑源性神经营养因子(BDNF)]水平,治疗前后的认知功能指标[简易精神状态量表(MMSE)、蒙特利尔认知评估量表(MOCA)]评分。结果观察组患者的治疗总有效率为90.38%,明显高于对照组的73.08%,差异具有统计学意义(P<0.05)。治疗后,观察组患者的GABA(58.08±2.12)μmol/L、Glu(35.09±1.34)μmol/L、NSE(9.65±1.63)μg/L、SOD(248.62±16.57)U/L均明显低于对照组的(64.90±2.19)μmol/L、(37.58±2.26)μmol/L、(14.67±3.58)μg/L、(312.63±18.32)U/L,BDNF(9.43±2.24)μg/L明显高于对照组的(7.21±2.18)μg/L,差异具有统计学意义(P<0.05)。治疗后,观察组患者的MMSE评分(31.03±2.68)分、MOCA评分(28.54±1.06)分均明显高于对照组的(27.24±2.59)、(26.17±1.12)分,差异具有统计学意义(P<0.05)。结论丙戊酸钠缓释片对老年癫痫患者的临床疗效显著,能提高对神经元异常兴奋的抑制作用,改善认知功能,具有积极的临床意义。Objective To discuss the effect of compound sodium valproate and valproic acid sustained release tablets on clinical efficacy and cognitive function in elderly patients with epilepsy.Methods A total of 104 elderly patients with epilepsy were randomly divided into control group and observation group,with 52 cases in each group.The control group was treated with carbamazepine tablets,and the observation group was treated with compound sodium valproate and valproic acid sustained release tablets.Both groups were compared in terms of clinical efficacy,serum indicators[γ-aminobutyric acid(GABA),glutamic acid(Glu),neuron-specific enolase(NSE),superoxide dismutase(SOD),brain-derived neurotrophic factor(BDNF)],cognitive function indicators[mini-mental state examination(MMSE),Montreal cognitive assessment scale(MOCA)]score before and after treatment.Results The total effective rate of treatment in the observation group was 90.38%,which was significantly higher than 73.08%in the control group,and the difference was statistically significant(P<0.05).After treatment,GABA(58.08±2.12)μmol/L,Glu(35.09±1.34)μmol/L,NSE(9.65±1.63)μg/L,SOD(248.62±16.57)U/L of the observation group were significantly lower than(64.90±2.19)μmol/L,(37.58±2.26)μmol/L,(14.67±3.58)μg/L,(312.63±18.32)U/L of the control group,and BDNF(9.43±2.24)μg/L was significantly higher than(7.21±2.18)μg/L of the control group.All the differences were statistically significant(P<0.05).After treatment,MMSE score(31.03±2.68)points and MOCA score(28.54±1.06)points of the observation group were significantly higher than(27.24±2.59)and(26.17±1.12)points of the control group,and the difference was statistically significant(P<0.05).Conclusion Compound sodium valproate and valproic acid sustained release tablets has significant clinical efficacy on elderly patients with pilepsy,and it can improve the inhibition of abnormal excitability of neurons and cognitive function,which contains positive clinical significance.

关 键 词：老年癫痫 丙戊酸钠缓释片 疗效 认知功能 

分 类 号：R742.1[医药卫生—神经病学与精神病学]