微小RNA在甲状腺乳头状癌中的异常表达和研究进展  

Abnormal Expression and Research Progress of MicroRNA in Papillary Thyroid Carcinoma

作　　者：娄永庆 陈红跃[2] 杨萌萌[1] 武红园 段祥凯 LOU Yong-qing;CHEN Hong-yue;YANG Meng-meng;WU Hong-yuan;DUAN Xiang-kai(Henan University of Traditional Chinese Medicine,Zhengzhou,Henan 450002;Department of Thyroid and Mammary Gland,Henan Provincial Hospital of Traditional Chinese Medicine,Zhengzhou,Henan 450002)

机构地区：[1]河南中医药大学,河南郑州450002 [2]河南省中医院甲状腺乳腺科,河南郑州450002

出　　处：《智慧健康》2021年第22期37-38,41,共3页Smart Healthcare

基　　金：河南省中医药科学研究专项课题(项目编号:20-21ZY2051)。

摘　　要：甲状腺癌(Thyroid Carcinoma,TC)是内分泌系统中最常见的恶性肿瘤之一,近年来发病趋势迅猛,已对人类生命健康构成重大威胁.微小RNA(microRNA,miRNA)是一类进化上高度保守、内源性的单链非编码小RNA,在多种生物的代谢过程中承担着重要角色,包括细胞的增殖、分化、凋亡及信号转导途径,与具有高侵袭性特征的甲状腺癌密切相关.先前研究报道,miRNA含量在多种类型恶性肿瘤患者的循环血液中异常表达,可作为致癌基因或抑癌基因,参与肿瘤发生发展过程,有望成为未来肿瘤诊断和药物治疗的新靶标.现就甲状腺肿瘤相关的miRNA最新的研究进展作一综述.Thyroid Carcinoma(TC)is one of the most common malignant tumors in the endocrine system.In recent years,the incidence trend has been rapid,and it has posed a major threat to human life and health.MicroRNA(miRNA)is a type of evolutionary highly conserved,endogenous single-stranded non-coding small RNA,which plays an important role in the metabolic process of a variety of organisms,including cell proliferation,differentiation,apoptosis and signaling.The transduction pathway is closely related to the highly aggressive thyroid cancer.Previous studies have reported that miRNA content is abnormally expressed in the circulating blood of patients with various types of malignant tumors,and can be used as oncogenes or tumor suppressor genes to participate in the development and development of tumors.It is expected to become a new target for tumor diagnosis and drug treatment in the future.This article summarizes the latest research progress of miRNAs related to thyroid tumors.

关 键 词：甲状腺癌 微小RNA 非编码RNA 

分 类 号：R736.1[医药卫生—肿瘤]