泌尿系肿瘤中m6A甲基化与非编码RNA互作的研究进展  

Interaction between N6-methyladenosine and non-coding RNAs in urological malignancy:an update

作　　者：倪金良 谢金波 彭波(审校)[1] I Jinliang;XIE Jinbo;PENG Bo(Department of Urology,Tenth People's Hospital,Tongji University School of Medicine,Shanghai,200072,China)

机构地区：[1]同济大学附属第十人民医院泌尿外科,上海200072

出　　处：《临床泌尿外科杂志》2021年第10期827-833,共7页Journal of Clinical Urology

基　　金：国家自然科学基金面上项目(No:32070646);上海市科学技术委员会科研计划项目(No:19140905700)

摘　　要：泌尿系统恶性肿瘤严重影响着患者的生命健康,目前临床治疗效果并不理想。N6-甲基腺苷RNA甲基化(N6-methyladenosine,m6A)是一种常见的RNA修饰方式,相关研究表明m6A与非编码RNA(non-cod-ing RNAs,ncRNAs)之间相互作用在多种泌尿系统恶性肿瘤发生、发展、侵袭、转移和预后密切相关,这为设计新的分子治疗方案提供研究方向。本文简述了m6A和ncRNAs之间相互调节作用,归纳了m6A和ncRNAs与泌尿系统恶性肿瘤之间的关系,主要包括前列腺癌、膀胱癌和肾癌,以提高对泌尿系统恶性肿瘤发病机制的认识,并且为泌尿系统恶性肿瘤治疗策略提供新的思路。Urinary malignancy seriously affects the health of patients and the clinical treatment effect is not i-deal at present.N6-methyladenosine(m6A)RNA methylation is a common RNA modification and related studies have shown that the interaction between m6Aand non-coding RNAs(ncRNAs)is closely associated with the oc-currence,progression,invasion,metastasis and prognosis of urological malignancies,which provides a research direction for the design of new molecular therapy protocols.This study introduced the interaction between m6A and ncRNAs.We summarized the relationship between m6A,ncRNAs and urological malignancy,including pros-tate cancer,bladder cancer and renal cell carcinoma to improve the understanding of the pathogenesis of urinary malignancy and to provide a new idea for the treatment of urinary malignancy.

关 键 词：N6-甲基腺苷RNA甲基化 非编码RNA 泌尿系统恶性肿瘤 

分 类 号：R737.1[医药卫生—肿瘤]