microRNA在喉鳞状细胞癌中的研究进展  

Research progress of microRNA in laryngeal squamous cell carcinoma

作　　者：卜倩倩 高伟[1] 吴勇延[1] 郭培钰 王斌全[1] BU Qianqian;GAO Wei;WU Yongyan

机构地区：[1]山西医科大学第一医院耳鼻咽喉头颈外科耳鼻咽喉头颈肿瘤山西省重点实验室,太原030001

出　　处：《临床耳鼻咽喉头颈外科杂志》2021年第10期947-951,共5页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：喉癌是头颈部常见的恶性肿瘤之一,喉鳞状细胞癌(laryngeal squamous cell carcinoma, LSCC)在喉癌中占95%以上[1],是头颈部肿瘤中最典型的组织学类型。LSCC是一种极具侵袭性的恶性肿瘤,致病原因主要与吸烟饮酒、空气污染、人乳头瘤病毒感染、慢性炎症等因素有关,但是具体的发病机制仍不清楚[2]。LSCC的男性发病率高于女性[3]。但是在过去的几十年里,男性和女性LSCC发病率均有所上升[4]。Laryngeal carcinoma is one of the most common malignant tumors in the area of head and neck, and the main pathological type is laryngeal squamous cell carcinoma. Due to the fact that the disease usually have no overt clinical symptoms at the early stage and easy to relapse, it has a poor prognosis and low five-year survival rate. microRNA is a class of endogenous, non-coding RNA with a length of 19-25 nucleotides. microRNAs, mainly regulate the expression of target genes at the post-transcriptional level after complementing and pairing with the 3’-UTR area of the target gene. Studies have shown that the abnormal expression of microRNA is closely related to the occurrence, development, metastasis and prognosis of various cancers including laryngeal carcinoma. In this article, the research progress of microRNA in laryngeal squamous cell carcinoma is reviewed.

关 键 词：喉肿瘤 癌 鳞状细胞 MICRORNA 

分 类 号：R739.65[医药卫生—肿瘤]