雌激素缺乏对泪腺组织影响的研究进展  

Research progress of the effect of estrogen deficiency on the lacrimal gland

作　　者：赵梓妍 丁怡[2] 马建民 Zhao Ziyan;Ding Yi;Ma Jianmin(Master's degree 2018,Department of Ophthalmology,Laboratory of Applied Pharmacology,Weifang Medical University,Weifang 261053,China;Department of Pathophysiology,Laboratory of Applied Pharmacology,Weifang Medical University,Weifang 261053,China;Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Ophthalmology and Visual Sciences Key Laboratory,Beijing 100730,China)

机构地区：[1]潍坊医学院应用药理学实验室,261053 [2]潍坊医学院病理生理学教研室,应用药理学实验室,261053 [3]首都医科大学附属北京同仁医院,北京同仁眼科中心,北京市眼科研究所,眼科学与视觉科学北京市重点实验室,100730

出　　处：《中华眼科医学杂志（电子版）》2021年第4期252-256,共5页Chinese Journal of Ophthalmologic Medicine(Electronic Edition)

基　　金：北京市自然基金课题(7182038);北京市医院管理中心"登峰"人才培养计划项目(DFL20190201);山东中医经典名方协同创新中心项目(2019KF203)。

摘　　要：雌激素水平对维持泪腺功能和组织结构的正常至关重要。雌激素缺乏会对泪腺产生不良影响,可以导致一些免疫相关性泪腺疾病的发生。泪腺腺泡细胞凋亡及炎性细胞浸润是泪腺组织自身免疫疾病的主要病理特点。雌激素是重要的"抗凋亡"物质,对泪腺细胞起保护作用。围绝经期女性雌激素降低或缺乏,保护作用减弱,泪腺细胞凋亡增加。凋亡产物可作为自身抗原,激活浆细胞样树突状细胞(PDC),促进炎性细胞浸润,分泌细胞因子,促进自身免疫疾病的发生。Estrogen is essential for maintaining the structure and function of lacrimal gland.Estrogen deficiency can adversely affect the lacrimal glands,which can cause some lacrimal autoimmune diseases.The main pathological characteristics of lacrimal autoimmune diseases are acinar cell apoptosis and inflammatory cell infiltration.Estrogen plays a great role in anti-apoptosis,which can protect the lacrimal gland cells from apoptotic programmed death.During perimenopausal period,estrogen deficiency will increase the number of apoptotic cells in female.The product produced after apoptosis process,as the autologous antigen,can activate the plasmacytoid dendritic cells(PDC)that promote inflammatory cell to infiltrate and secrete cytokines,which can cause the autoimmune diseases.

关 键 词：雌激素 泪腺疾病 细胞凋亡 炎性细胞浸润 浆细胞样树突状细胞 

分 类 号：R777.21[医药卫生—眼科]