立体定向放疗联合支气管动脉介入治疗晚期肺癌的临床效果  

Effects of Stereotactic Radiotherapy Combined with Bronchial Artery Intervention in the Treatment of Advanced Lung Cancer

作　　者：王向阳 周素静 赵石垒 WANG Xiangyang;ZHOU Sujing;ZHAO Shilei(Department of Interventional Medicine,Xuchang Central Hospital,Xuchang 461000,China)

机构地区：[1]许昌市中心医院介入科,河南许昌461000

出　　处：《河南医学研究》2021年第34期6457-6459,共3页Henan Medical Research

摘　　要：目的探讨立体定向放疗联合支气管动脉介入在晚期肺癌治疗中的应用效果。方法选取2018年2月至2020年2月许昌市中心医院收治的76例晚期肺癌患者作为研究对象,依据门诊号的单双号分为观察组(双号)和对照组(单号),各38例。对照组在化疗基础上接受立体定向放疗,观察组在对照组治疗基础上接受支气管动脉介入治疗。两组均随访至少1 a。比较两组治疗3个月的总缓解率,记录两组治疗期间发生的毒副反应(放射性肺炎、白细胞减少、血小板减少等)。统计并比较两组随访1 a期间的生存情况。结果观察组治疗3个月总缓解率高于对照组(P<0.05)。两组治疗期间毒副反应发生率比较,差异无统计学意义(P>0.05)。随访1 a,患者均获得随访结果,观察组总体生存时间长于对照组,差异有统计学意义(P<0.05)。结论立体定向放疗联合支气管动脉介入治疗晚期肺癌可提高临床效果,延长患者生存期,且不增加毒副反应。Objective To investigate the application effect of stereotactic radiotherapy combined with bronchial artery intervention in the treatment of advanced lung cancer.Methods A total of 76 patients with advanced lung cancer treated in Xuchang Central Hospital from February 2018 to February 2020 were selected as the research subjects,according to the odd or even number of outpatient numbers,they were divided into observation group(even number)and control group(odd number),with 38 cases in each group.The control group was treated with stereotactic radiotherapy on the basis of chemotherapy,and the observation group was treated with bronchial artery intervention on the basis of the control group,both groups were followed up for at least 1 year.The total remission rate of the two groups after 3 months of treatment was compared.The toxic and side effects(radiation pneumonia,leucopenia,thrombocytopenia,etc.)during the treatment of the two groups were recorded.The survival of the two groups during one year of follow-up was counted and compared.Results After 3 months of treatment,compared with the control group,the total remission rate was higher and the overall curative effect was better of the observation group(P<0.05).There was no statistical difference in comparison of the total incidence of toxic and side effects between the two groups(P>0.05).Followed up for 1 year,all patients gained the follow-up results,compared with the control group,the overall survival time was longer of the observation group(P<0.05).Conclusion Stereotactic radiotherapy combined with bronchial artery intervention in the treatment of advanced lung cancer can improve the curative effect,prolong the survival time of patients,and will not increase toxic and side effects.

关 键 词：肺癌 立体定向放疗 支气管动脉介入 毒副反应 总缓解率 

分 类 号：R734.2[医药卫生—肿瘤]