环状RNA在非小细胞肺癌放疗抵抗中的研究进展  

Research Progress in CircRNA and Radiotherapy Resistance of Non-small Cell Lung Cancer

作　　者：李炜龙 马胜林[2] 张仕蓉 Weilong LI;Shenglin MA;Shirong ZHANG(Zhejiang Chinese Medical University,Hangzhou 310053,China;Hangzhou Cancer Hospital,Hangzhou 310002,China;The Four School of Medicine,Zhejiang Chinese Medical University,Hangzhou First People’s Hospital,Hangzhou 310006,China)

机构地区：[1]浙江中医药大学,杭州310053 [2]杭州市肿瘤医院,杭州310002 [3]浙江中医药大学第四临床医学院,杭州市第一人民医院,杭州310006

出　　处：《中国肺癌杂志》2021年第11期770-776,共7页Chinese Journal of Lung Cancer

基　　金：浙江省自然科学基金(No.LY19H160032)资助。

摘　　要：非小细胞肺癌(non-small cell lung cancer,NSCLC)作为临床上较为常见的癌症,主要特点是患者5年生存率低、预后偏差。目前有部分研究认为生存率低、预后偏差是由于环状RNA(circluar RNA,circRNA)引起了放疗抵抗。因此,找出circRNA与NSCLC放疗抵抗之间的联系,可为改善临床治疗提供理论基础。通过查阅相关文献,找出circRNA与NSCLC放疗抵抗的关系。CircRNA在NSCLC细胞的侵袭、转移、增殖和治疗抵抗中起着重要的作用,其中它所诱导的肿瘤细胞放疗抵抗已经成为放射治疗上的一个重点关注问题。CircRNA在NSCLC的放疗抵抗中起着重要作用。As the main type of lung cancer,non-small cell lung cancer(NSCLC)is a common cancer which is characterized by low 5-year survival rate and worse prognosis.Nowadays,some studies show that the low survival rate and worse prognosis are due to the resistance to radiotherapy caused by circRNA.Therefore,to find out the relationship between circRNA and radiotherapy resistance of NSCLC was imoprtant.According to research the relevant literatures,the relationship between circRNA and radiotherapy resistance of NSCLC was explored.CircRNA plays an important role in the invasion,metastasis,proliferation and treatment resistance of NSCLC.The radiation resistance of tumor cells induced by circRNA has become a crucial problem in radiotherapy.CircRNA plays an important role in the radiotherapy resistance of NSCLC.

关 键 词：肺肿瘤 CircRNA 放疗 抵抗 研究进展 

分 类 号：R734.2[医药卫生—肿瘤]