基于开端同轴探头技术的人体正常食管和食管癌介电特性比较  

Comparison of dielectric properties of normal human esophagus and esophageal cancer using an open-ended coaxial probe

作　　者：黄强 卢笛[2] 韩继钧 于洪峰 董文[2] 蔡开灿[2] 余学飞[1] HUANG Qiang;LU Di;HAN Jijun;YU Hongfeng;DONG Wen;CAI Kaican;YU Xuefei(School of Biomedical Engineering,Southern Medical University,Guangzhou 510515,China;Department of Thoracic Surgery,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;School of Biomedical Engineering,Anhui Medical University,Hefei 230032,China;Department of Medical Equipment,Hangzhou Fuyang Orthopedic Hospital of Traditional Chinese Medicine,Hangzhou 311400,China)

机构地区：[1]南方医科大学生物医学工程学院,广东广州510515 [2]南方医科大学南方医院胸外科,广东广州510515 [3]安徽医科大学生物医学工程学院,安徽合肥230032 [4]杭州市富阳中医骨伤医院设备科,浙江杭州311400

出　　处：《南方医科大学学报》2021年第11期1741-1746,共6页Journal of Southern Medical University

基　　金：广州市产学研协同创新重大专项(201704020091);南方医科大学南方医院院长基金面上项目(2020B011);南方医科大学南方医院临床研究专项(2018CR053);广东省医学科学技术研究基金项目(C2021049);。

摘　　要：目的研究食管癌手术中切除的人体正常食管组织和食管癌组织的介电特性(相对介电常数εr和电导率σ)差异,为临床食管癌手术中快速鉴别提供一种新的理论依据。方法采用开端同轴探头法在50 MHz~4 GHz频率范围内,对51名食管癌患者手术切除的标本正常部分及肿瘤部分进行介电测量。在全频段分析其介电特性差异,并且对6个特定频率点(64、128、298、433、915、2450 MHz)的数据进行统计学分析,此外采用Cole-Cole模型在整个频段内对数据进行拟合并且将测量值与文献值进行对比。结果在50 MHz~4 GHz频率范围内食管癌组织的介电特性值高于正常食管组织;在6个频率点正常食管组织和食管癌组织介电特性存在显著性差异(P<0.01);Cole-Cole模型对测量的数据有较好的拟合结果;本研究的测量值低于文献值。结论正常食管组织与肿瘤组织介电特性存在显著性差异,有望为临床食管癌术中快速鉴别提供一种新的理论依据。Objective To study the difference in dielectric properties(relative permittivity and electrical conductivity)between normal human esophageal tissues and esophageal cancer tissues resected in esophageal cancer surgery for rapid identification of esophageal cancer during surgery.Methods An open-end coaxial probe in the frequency range of 50 MHz to 4 GHz was used for dielectric measurement of the normal tissues and tumor tissues immediately after resection in 51 esophageal cancer cases.The difference in dielectric characteristics of the tissues was analyzed in the full frequency range,and the measurement data at 6 specific frequencies(64,128,298,433,915,and 2450 MHz)were analyzed statistically.The Cole-Cole model was used for data fitting in the entire frequency band and the measured values were compared with reported values.Results In the frequency range of 50 MHz-4 GHz,the dielectric measurement values of esophageal cancer tissues were significantly higher than those of normal esophageal tissues.At the 6 specific frequencies,the dielectric properties also differed significantly between normal esophageal tissues and esophageal cancer tissues(P<0.01).The Cole-Cole model achieved a good fitting result of the measured data.The measured values in this study were lower than the reported values.Conclusion There are significant differences in the dielectric properties between normal esophageal tissue and tumor tissue,which may provide a new theoretical basis for rapid identification of esophageal cancer during surgery.

关 键 词：食管癌 介电特性 开端同轴探头 

分 类 号：R735.1[医药卫生—肿瘤]