1例药物诱发天疱疮的诊治体会  

Experience in the diagnosis and treatment of a drug-induced pemphigus

作　　者：袁培养 邱敏 万梓欣 江潞[1] Yuan Peiyang;Qiu Min;Wan Zixin;Jiang Lu(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Dept.of Oral Medicine,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China;Dept.of Oral Medicine,Stomatology Center,Shenzhen People,s Hospital,Shenzhen 518020,China;State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Dept.of Oral Pathology,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医院黏膜病科,成都610041 [2]深圳市人民医院口腔医学中心口腔内科,深圳518020 [3]口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医院病理科,成都610041

出　　处：《华西口腔医学杂志》2021年第6期724-727,共4页West China Journal of Stomatology

基　　金：国家自然科学基金(81670998,81872208)。

摘　　要：药物诱发天疱疮(DIP)是天疱疮的一种特殊类型,其发病机制及治疗预后特点与其诱发药物密切相关。本文报道1例结核病患者服用利福平导致DIP(寻常型天疱疮)的诊治经过,并结合文献讨论DIP的类型、发病机制、鉴别诊断与治疗原则,建议在口腔临床实践中对诊断为寻常型天疱疮的患者应特别强调排查DIP的可能性。Drug-induced pemphigus(DIP)is a special type of pemphigus,and its pathogenesis,characteristics of treatment,and prognosis are closely related to the inducing drugs.This article reports the diagnosis and treatment of DIP(pemphigus vulgaris)caused by the administration of rifampin to a patient with tuberculosis.Combined with the literature,we discussed the types,pathogenesis,differential diagnosis,and treatment principles of DIP.We propose that in the oral clinical practice for patients with pemphigus vulgaris,the importance of investigating suspected drugs that induce DIP should be emphasized.

关 键 词：药物诱发天疱疮 利福平 寻常型天疱疮 结核病 

分 类 号：R781.5[医药卫生—口腔医学]