血浆D-二聚体、同型半胱氨酸、纤维蛋白原与急性脑梗死关系及其对预后的预测价值  

Relationship between Plasma D-dimer, Homocysteine, Fibrinogen and Acute Cerebral Infarction and Its Predictive Value for Prognosis

作　　者：汪闯 薛春萍[1] 郑良鹏 熊珍[1] 陶淼 WANG Chuang;XUE Chunping;ZHENG Liangpeng;XIONG Zhen;TAO Miao(Macheng People’s Hospital,Macheng 438300,China;不详)

机构地区：[1]麻城市人民医院,湖北麻城438300

出　　处：《中外医学研究》2021年第32期84-87,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析血浆D-二聚体(D-D)、同型半胱氨酸(Hcy)、纤维蛋白原(FIB)与急性脑梗死的关系及其对患者预后的预测价值。方法:选取2019年6月-2020年12月来本院治疗的急性脑梗死患者38例作为观察组,同时选取同期来本院体检中心进行健康查体的体检者38例作为对照组。取观察组和对照组静脉血检测血浆D-D、Hcy、FIB水平,比较两组血浆D-D、Hcy和FIB水平,分析其与脑梗死严重程度和脑梗死面积的关系及预后预测的价值。结果:观察组血浆D-D、Hcy、FIB水平均高于对照组(P<0.05);重度脑梗死患者血浆D-D、Hcy、FIB水平高于中度脑梗死患者,中度脑梗死患者高于轻度脑梗死患者,且差异有统计学意义(P<0.05);不同脑梗死面积患者血浆D-D、Hcy、FIB水平比较显示,梗死面积越大,患者血浆D-D、Hcy、FIB水平越高(P<0.05);血浆D-D、Hcy、FIB的AUC值分别为0.917、0.900、0.754,三者对急性脑梗死患者预后预测具有一定的价值,差异有统计学意义(P<0.05)。结论:血浆D-D、Hcy、FIB水平越高,患者梗死面积越大,且三者水平的监测对预测患者预后有一定的价值。Objective:To analyze the relationship between plasma D-dimer (D-D),homocysteine (Hcy),fibrinogen (FIB) and acute cerebral infarction and its predictive value for the prognosis of patients.Method:A total of 38 patients with acute cerebral infarction who came to our hospital for treatment from June 2019 to December 2020 were selected as the observation group,and 38 patients who came to our hospital for health examination department for physical examination during the same period were selected as the control group.The venous blood of the observation group and the control group was taken to detect plasma D-D,Hcy,and FIB levels.The plasma D-D,Hcy,and FIB levels in the two groups were compared,and the relationship between the levels of plasma D-D,Hcy and FIB and the severity of cerebral infarction and the size of cerebral infarction and the prognostic value were analyzed.Result:The plasma D-D,Hcy,and FIB levels of the observation group were higher than those of the control group (P<0.05).The levels of plasma D-D,Hcy and FIB in patients with severe cerebral infarction were higher than those with moderate cerebral infarction,and patients with moderate cerebral infarction were higher than those with mild cerebral infarction,and the differences were statistically significant (P<0.05);comparison of plasma D-D,Hcy and FIB levels in patients with different cerebral infarction areas showed that the larger the infarction area,the higher the plasma D-D,Hcy,and FIB levels of patients (P<0.05);the AUC values of plasma D-D,Hcy,FIB were 0.917,0.900,and 0.754 respectively,which had certain value in predicting the prognosis of patients with acute cerebral infarction,and the differences were statistically significant (P<0.05).Conclusion:The higher the plasma D-D,Hcy and FIB levels,the larger the infarct area of the patients,and the monitoring of the levels of the plasma D-D,Hcy and FIB has a certain value in predicting the prognosis of the patient.

关 键 词：D-二聚体 同型半胱氨酸 纤维蛋白原 急性脑梗死 预后预测 

分 类 号：R743.33[医药卫生—神经病学与精神病学]