盐酸丁螺环酮联合利培酮改善首发精神分裂症患者认知功能效果研究  

Effect of Buspirone Hydrochloride Combined with Risperidone on Cognitive Function in Patients with First-Episode Schizophrenia

作　　者：蔺华利[1] 姚艳 张海艳[1] 刘祥芹[1] 王锦[1] 张宏伟 石锦娟[1] LIN Huali;YAO Yan;ZHANG Haiyan;LIU Xiangqin;WANG Jin;ZHANG Hongwei;SHI Jinjuan(Xi'an Mental Health Center,Xi'an,Shaanxi,China 710061;Xi'an Medical University,Xi'an,Shaanxi,China 710068)

机构地区：[1]陕西省西安市精神卫生中心,陕西西安710061 [2]西安医学院,陕西西安710068

出　　处：《中国药业》2021年第23期89-92,共4页China Pharmaceuticals

基　　金：陕西省重点研发计划项目[2017SF-293];陕西省西安市卫计委卫生科研人才培训项目[J201803044]。

摘　　要：目的探讨盐酸丁螺环酮联合利培酮改善首发精神分裂症患者认知功能的临床效果。方法选取陕西省西安市精神卫生中心2018年5月至2020年6月收治的首发精神分裂症患者100例,按随机数字表法分为研究组和对照组,各50例。两组患者均予利培酮治疗,研究组患者加用盐酸丁螺环酮。治疗前、治疗8周末及治疗12周末,采用精神分裂症认知功能成套测验共识版(MCCB)评估认知功能,以阳性和阴性症状量表(PANSS)评估临床症状,以副反应量表(TESS)评估不良反应。结果研究组失访1例、存在顾虑2例,对照组肝功能异常1例、视物不清1例,均予以剔除。与治疗前相比,治疗8周末和治疗12周末,研究组患者的所有认知维度评分均明显改善(P<0.05),对照组患者仅信息处理速度评分和所有维度总分均明显改善(P<0.05);与治疗8周末相比,治疗12周末研究组患者除工作记忆及语言学习外,其他认知维度评分均明显改善(P<0.05),对照组患者仅信息处理速度评分和所有维度总分均明显改善(P<0.05);与对照组相比,治疗8周末和治疗12周末,研究组患者仅注意/警觉评分明显改善(P<0.05);与治疗前相比,治疗8周末和治疗12周末,两组患者的阳性症状、阴性症状和一般精神症状评分均明显下降(P<0.05),但治疗12周末研究组仅阳性症状评分明显低于对照组(P<0.05);治疗前、治疗8周末、治疗12周末,研究组患者的注意/警觉与阳性症状评分间均无相关性(r=-0.38,-0.19,-0.47,P>0.05)。治疗期间,研究组和对照组患者不良反应发生率相当(17.02%比22.92%,P>0.05)。结论盐酸丁螺环酮联合利培酮改善首发精神分裂症患者的认知功能效果显著,尤其在注意/警觉和阳性症状评分方面优于单用利培酮。Objective To investigate the effect of buspirone hydrochloride combined with risperidone on cognitive function in patients with first-episode schizophrenia.Methods A total of 100 patients with first-episode schizophrenia admitted to the Xi'an Mental Health Center from May 2018 to June 2020 were selected and divided into the study group and the control group by the random num-ber table method,50 cases in each group.The patients in the two groups were treated with risperidone,on this basis,the patients in the study group were treated with buspirone hydrochloride.Before treatment,at the end of the 8th week and the 12th week of treatment,the patients'cognitive function was assessed by the MATRICS Consensus Cognitive Battery(MCCB),the patients'clinical symptoms were assessed by the Positive and Negative Symptom Scale(PANSS),and the adverse drug reactions were assessed by the Treatment Emer-gent Symptom Scale(TESS).Results One case was lost to follow-up and two cases had apprehension in the study group,one case of abnormal liver function and one case of unclear vision in the control group,all of them were excluded.Compared with those before treatment,the scores of all cognitive dimensions in the study group were significantly improved at the end of the 8th and 12th weeks of treatment(P<0.05),while only the score of information processing speed and total score of all cognitive dimensions in the control group were significantly improved(P<0.05).Compared with those at the end of the 8th week of treatment,the scores of cognitive dimensions except working memory and language learning in the study group were significantly improved(P<0.05),while only the score of information processing speed and total score of all cognitive dimensions in the control group were significantly improved(P<0.05).Compared with those in the control group,the score of attention/alertness of patients in the study group was significantly improved at the end of the 8th and 12th weeks(P<0.05).Compared with those before treatment,the scores of positive sy

关 键 词：利培酮 盐酸丁螺环酮 首发精神分裂症 认知功能 

分 类 号：R969.4[医药卫生—药理学] R971.41[医药卫生—药学]