可溶性膳食纤维预防盆腔放疗所致胃肠道毒性的Meta分析  

Meta-analysis of soluble dietary fiber in prevention of gastrointestinal toxicity induced by pelvic radiotherapy

作　　者：李芷茹 李超 刘颖[3] 李兰[3] LI Zhi-ru;LI Chao;LIU Ying;LI Lan(Department of Oncology,Zigong First People′s Hospital,Zigong 643000,China;Department of Obstetrics and Gynecology,Zigong First People′s Hospital,Zigong 643000,China;Department of Obstetrics and Gynecology,Chengdu Fifth People′s Hospital,Chengdu 611130,China)

机构地区：[1]四川省自贡市第一人民医院肿瘤科,自贡市643000 [2]四川省自贡市第一人民医院妇产科,自贡市643000 [3]四川省成都市第五人民医院妇产科,成都市611130

出　　处：《广西医学》2021年第19期2331-2335,共5页Guangxi Medical Journal

摘　　要：目的系统评价可溶性膳食纤维预防盆腔放疗引起的胃肠道毒性的效果。方法计算机检索PubMed、Embase、Medline、ClinicalTrials.gov、Ovid、Cochrane Library、知网、万方、维普、中国生物医学文献等数据库,并辅以手工检索相关期刊,纳入有关应用膳食纤维预防盆腔放疗所致胃肠道毒性的随机对照试验。筛选文献并行质量评价后,采用RevMan 5.2软件进行Meta分析。结果纳入5篇随机对照试验共397例患者。Meta分析结果显示,摄入可溶性膳食纤维可以降低腹泻发生率(P<0.05)。在采用欧洲癌症治疗研究组织生活质量调查问卷评估生活质量的文献中,摄入可溶性膳食纤维不能改善患者放疗期间生活质量(P>0.05);在采用炎症性肠病生活质量量表进行评估的文献中,摄入高水平可溶性纤维或可改善患者放疗期间的生活质量(P<0.05)。结论可溶性膳食纤维可有效地降低盆腔放疗所致的腹泻发生率,但尚不能明确其能否改善患者放疗期间的生活质量。Objective To systematically evaluate the preventive effect of soluble dietary fiber on gastrointestinal toxicity induced by pelvic radiotherapy.Methods A computer-based retrieval was conducted in databases such as PubMed,Embase,Medline,ClinicalTrials.gov,Ovid,the Cochrane Library,CNKI,Wanfang Data,VIP and SinoMed for randomized controlled trials(RCTs),an adjuvant manual search was conducted in related journals,and randomized controlled trials related to the application of dietary fiber to prevent pelvic radiotherapy-induced gastrointestinal toxicity were enrolled.After literature screening and quality assessment,RevMan 5.2 software was used to perform a Meta-analysis.Results Five RCTs involving 397 patients were included.The results of Meta-analysis showed that the soluble dietary fiber intake could reduce the incidence rate of diarrhea(P<0.05).In the documents using the European Organization for Research and Treatment of Cancer-Quality of Life Questionnaire-Core 30 to evaluate quality of life,it was described that soluble dietary fiber intake could not improve patients′quality of life during radiotherapy(P>0.05);in the documents about assessment using the inflammatory bowel disease questionnaire,it was described that a high-level soluble fiber intake might improve patients′quality of life during radiotherapy(P<0.05).Conclusion Soluble dietary fiber can effectively reduce the incidence rate of diarrhea caused by pelvic radiotherapy,but whether it can improve patients′quality of life during radiotherapy is still uncertain.

关 键 词：膳食纤维 盆腔放疗 胃肠道毒性 腹泻 生活质量 预防 META分析 

分 类 号：R459.3[医药卫生—治疗学]