洋金花的化学成分、药理作用及临床应用研究进展  

Research Progress on Chemical Constituents,Pharmacological Effect and Clinical Applications of Daturae Flos

作　　者：朱金莲 邓颖嘉 何燕珊 王瑞 匡海学[2] 王秋红 ZHU Jin-lian;DENG Ying-jia;HEYan-shan;WANG Rui;KUANG Hai-xue;WANG Qiu-hong(Guangdong Engineering and Technology Research Center of Standardized Processing of Chinese Materia Medica Decoction Pieces,School of Traditional Chinese Medicine(TCM),Guangdong Pharmaceutical University,Guangzhou 511400,China;Key Laboratory of Basic and Applied Research of Northern Medicine,Ministry of Education,Heilongjiang Key Laboratory of Pharmacodynamic Material Basis of TCM and Natural Medicine,Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]广东药科大学中药学院,广东省中药饮片规范化炮制工程技术研究中心,广州511400 [2]黑龙江中医药大学教育部北药基础与应用研究重点实验室,黑龙江省中药及天然药物药效物质基础研究重点实验室,哈尔滨150040

出　　处：《中国实验方剂学杂志》2021年第23期201-209,共9页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家重点研发计划“中医药现代化研究”重点专项(2018YFC17007100);国家自然科学基金面上项目(8177141630);国家“重大新药创制”科技重大专项(2018ZX09731-001)。

摘　　要：洋金花为止咳平喘药,其花和叶中富含多种化合物,包括醉茄内酯类、生物碱类、萜类、黄酮类及酰胺类等成分。因其具有平喘止咳、解痉定痛的功效,传统上常用于治疗哮喘咳嗽、脘腹冷痛、风湿痹痛、小儿慢惊,还可作为外科麻醉的原料药。现代药理研究表明,洋金花除了具有平喘止咳、解痉定痛等传统功效外,还具有抗炎、免疫抑制、抗惊厥、抗癫痫、抗肿瘤等作用,常用于银屑病、帕金森病、癫痫、类风湿性关节炎等疾病的治疗。目前,有关洋金花的化学成分研究主要集中在醉茄内酯类及生物碱成分;同时,洋金花化学成分类别划分比较笼统,化学成分在不同药用部位中的分布情况也不太清楚,多糖成分药理作用研究相对较少。基于此,笔者拟系统检索洋金花国内外的相关文献,对其不同结构类型的化学成分、药理作用及临床应用进行了总结与分析,以期为洋金花的进一步开发与利用提供参考。Daturae Flos is a traditional antitussive and antiasthmatic medicine,its flowers and leaves are rich in a variety of compounds,including withanolides,alkaloids,terpenes,flavonoids and amides.Because of its antiasthmatic,antitussive,antispasmodic and analgesia effect,it is traditionally used for the treatment of asthma,cough,cold pain in abdominal cavity,rheumatic arthralgia,infantile chronic eclampsia,and can also be used as raw material for surgical anesthesia.Modern pharmacological studies have shown that in addition to the traditional efficacy,Daturae Flos also has anti-inflammatory,immunosuppression,anti-convulsion and other effects,and is often used in the treatment of psoriasis,Parkinson’s disease,epilepsy,rheumatoid arthritis and other diseases.At present,the chemical constituents of Daturae Flos are mainly focused on withanolides and alkaloids.At the same time,there is a lack of clear classification of chemical components and the distribution of chemical components in medicinal parts of this medicine,and little information is available for the pharmacological effects of polysaccharides.Based on this,this paper systematically searched relevant literature of Daturae Flos,and summarized and analyzed its chemical composition,pharmacological effect and clinica application,in order to provide reference for further development and utilization of Daturae Flos.

关 键 词：洋金花 醉茄内酯 萜类 麻醉 平喘止咳 银屑病 抗炎 

分 类 号：R22[医药卫生—中医基础理论] R932[医药卫生—中医学]