液体活检在肝癌预后评估中的研究进展  

Recent advances in liquid biopsy for predicting prognosis of hepatocellular carcinoma

作　　者：何倩倩 邢昊 管鸣诚 李超 姚岚清 朱虹[1] 杨田 He Qianqian;Xing Hao;Guan Mingcheng;Li Chao;Yao Lanqing;Zhu Hong;Yang Tian(Department of Oncology,the First Affiliated Hospital of Soochow University,Suzhou 215006,China;Department of Hepatobiliary Surgery,Eastern Hepatobiliary Surgery Hospital of Naval Medical University,Shanghai 200438,China)

机构地区：[1]苏州大学附属第一医院肿瘤科,215006 [2]海军军医大学东方肝胆外科医院肝脏外科,上海200438

出　　处：《中华实验外科杂志》2021年第12期2555-2557,共3页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金(82171834、81972726、81871949、81572345);江苏省六大人才高峰项目(WSN-102);苏州市第四批姑苏卫生重点人才项目。

摘　　要：肝细胞癌是临床上常见的恶性肿瘤之一,其进展迅速,病死率高,总体预后极差,5年生存率不足18%。故临床上常应用分期系统等方法对肝细胞癌患者进行预后评估,但由于肝细胞癌的异质性极高,这些传统的工具无法对其预后进行精准预测。液体活检是近年来研究的热点,主要通过对体液中的小分子成分(包括循环肿瘤细胞、循环游离核酸、外泌体等)进行分析,进而实时反映肿瘤状况及其预后情况。因此,本文旨在探讨液体活检在肝细胞癌预后中的潜在作用。Hepatocellular carcinoma(HCC)is one of the most common malignant tumors globally.The rapid progression in HCC contributes to the high fatality rates and poor overall prognosis,with the 5-year survival of less than 18%.For this reason,several methods,including HCC staging systems,are often used to evaluate the prognosis of patients with HCC.However,due to the high heterogeneity of HCC,these traditional tools can not accurately predict its prognosis.In recent years liquid biopsy has become a hot topic,Liquid biopsy is a minimally invasive technology for the detection of molecular components(e.g.,circulating tumor cells,circulating cell-free nucleic acids,and exosomes)in body fluid,eventually reflecting the tumor status and its prognosis.Herein,the current review aimed to explore the potential role of liquid biopsy in the prognosis of HCC.

关 键 词：液体活检 肝细胞癌 预后 循环肿瘤细胞 循环游离核酸 外泌体 

分 类 号：R735.7[医药卫生—肿瘤]