扶正消瘤汤对湿热蕴结型晚期结直肠癌术后患者生存率、生活质量及血清白细胞介素6、肿瘤坏死因子α的影响  

Effect of Fuzheng Xiaoliu Decoction for survival rate,quality-of-life,serum interleukin 6,tumor necrosis factor-αin postoperative patients with colorectal cancer of damp-heat accumulation

作　　者：黄浩然 赵杉[1] 王如然[1] 张玉杰[1] 陈明国[1] 李宏燕[1] 许华颖[1] 肖阳春 HUANG Haoran;ZHAO Shan;WANG Ruran;ZHANG Yujie;CHEN Mingguo;LI Hongyan;XU Huaying;XIAO Yangchun(Department of Surgery,South District of Guang'anmen Hospital,Chinese Academy of Chinese Medicine Sciences,Beijing 102618;不详)

机构地区：[1]中国中医科学院广安门医院南区外科,北京102618 [2]北京市中医医院顺义医院急诊科,北京101300

出　　处：《河北中医》2021年第8期1266-1271,共6页Hebei Journal of Traditional Chinese Medicine

基　　金：北京市重点实验室2015年度开放课题(编号:2015ZYGR02)。

摘　　要：目的观察扶正消瘤汤对湿热蕴结型晚期结直肠癌术后患者生存率、生活质量及血清白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)的影响。方法将120例湿热蕴结型晚期结直肠癌术后患者按照随机数字表法分为2组,对照组60例予XELOX方案化疗,治疗组60例在对照组治疗基础上予扶正消瘤汤治疗。2组均21 d为1个化疗周期,共治疗4个周期。比较2组治疗前后及治疗后6个月中医证候评分、卡氏评分(KPS),2组治疗前后及治疗后1、3、6个月血清1L-6、TNF-α水平,随访5年统计2组生存情况,并统计2组近期实体瘤疗效。结果治疗组总有效率86.7%(52/60),对照组总有效率66.7%(40/60),治疗组实体瘤疗效优于对照组(P<0.05)。治疗后及治疗后6个月2组中医证候评分均较本组治疗前降低(P<0.05),治疗后6个月2组中医证候评分均较本组治疗后升高(P<0.05),且治疗后及治疗后6个月治疗组中医证候评分均低于对照组同期(P<0.05)。治疗后及治疗后1、3、6个月2组血清IL-6、TNF-α水平均较本组治疗前降低(P<0.05),治疗后1、3、6个月均较本组治疗后降低(P<0.05),治疗后3个月均较本组治疗后1个月降低(P<0.05),治疗后6个月治疗组血清IL-6水平较本组治疗后3个月降低(P<0.05),治疗后6个月对照组血清IL-6及2组TNF-α水平均较本组治疗后1、3个月升高(P<0.05);治疗后及治疗后1、3、6个月治疗组血清IL-6、TNF-α水平均低于对照组同期(P<0.05)。治疗后及治疗后6个月2组KPS均较本组治疗前升高(P<0.05),治疗后6个月2组KPS均较本组治疗后降低(P<0.05),且治疗后及治疗后6个月治疗组KPS均高于对照组同期(P<0.05)。治疗组中位生存时间长于对照组(P<0.05),1、2年生存率均高于对照组(P<0.05)。Pearson相关性分析显示,IL-6、TNF-α与分化程度、症状评分具有显著正相关(P<0.05),与中医治疗、生活质量、生存率存在显著负相关(P<0.05),与年龄、病理类型不存在相关性Objective To observe the effect of Fuzheng Xiaoliu Decoction for survival rate,quality-of-life,serum interleukin 6(IL-6),tumor necrosis factor-α(TNF-α)in postoperative patients with colorectal cancer(CRC)of damp-heat accumulation.Methods Totally 120 postoperative patients with CRC(damp-heat accumulation)were randomly divided into two groups,60 cases in control group were treated with XELOX therapy(capecitabine and oxaliplatin),and 60 cases in treatment group with Fuzheng Xiaoliu Decoction on the basis of control group,addinationlly.The treatment continued for 4 cycles(1 chemotherapy cycle for 21 d),the aim was to compare traditional Chinese medicine(TCM)syndrome scores and Karnofsky Performance Status(KPS)before and after treatment,and on the 6th month post-treatment;serum 1L-6 and TNF-αbefore and after treatment,and on the 1st,3rd,6th month post-treatment;5-year follow-up of survival rate;the curative effect of recent solid tumors was counted.Results The total effective rates in treatment group and control group were 86.7%(52/60)and 66.7%(40/60),respectively,the curative effect of solid tumors being better in treatment group than control group(P<0.05).Compared with before treatment,TCM syndrome scores in groups were decreased after treatment and on the 6th month post-treatment(P<0.05),treatment group decreased notably when compared with cortrol group(P<0.05),TCM syndrome scores in groups on the 6th month post-treatment were increased than that after treatment(P<0.05).Compared with before treatment,serum IL-6 and TNF-αin groups were decreased after treatment and on the 1st,3rd,6th month post-treatment(P<0.05),treatment group were significantly decreased(P<0.05);serum IL-6 and TNF-αin groups on the 1st,3rd,6th month post-treatment were decreased than those after treatment(P<0.05),which decreased notably on the 3rd month post-treatment when compared with the 1st month post-treatment(P<0.05);serum IL-6 on the 6th month post-treatment in treatment group remarkably decreased than those on the 3rd month post-treat

关 键 词：肠肿瘤 中药疗法 生活质量 白细胞介素6 肿瘤坏死因子Α 

分 类 号：R735.340.531[医药卫生—肿瘤]