COVID-19 as a trigger of irritable bowel syndrome:A review of potential mechanisms  

作　　者：Carlo Romano Settanni Gianluca Ianiro Francesca Romana Ponziani Stefano Bibbò Jonathan Philip Segal Giovanni Cammarota Antonio Gasbarrini 

机构地区：[1]UnitàOperativa Complessa Medicina Interna e Gastroenterologia,Dipartimento di Scienze Mediche e Chirurgiche,Fondazione Policlinico Universitario"A.Gemelli"IRCCS,Rome 00168,Italy [2]Istituto di Patologia Speciale Medica,UniversitàCattolica del Sacro Cuore,Rome 00168,Italy [3]Department of Gastroenterology and Hepatology,Hillingdon Hospital,Uxbridge HA13UJ,United Kingdom

出　　处：《World Journal of Gastroenterology》2021年第43期7433-7445,共13页世界胃肠病学杂志（英文版）

摘　　要：In December 2019 a novel coronavirus disease 2019(COVID-19),caused by the severe acute respiratory syndrome coronavirus-2(SARS-CoV-2),started spreading from Wuhan city of Chinese Hubei province and rapidly became a global pandemic.Clinical symptoms of the disease range from paucisymptomatic disease to a much more severe disease.Typical symptoms of the initial phase include fever and cough,with possible progression to acute respiratory distress syndrome.Gastrointestinal manifestations such as diarrhoea,vomiting and abdominal pain are reported in a considerable number of affected individuals and may be due to the SARS-CoV-2 tropism for the peptidase angiotensin receptor 2.The intestinal homeostasis and microenvironment appear to play a major role in the pathogenesis of COVID-19 and in the enhancement of the systemic inflammatory responses.Long-term consequences of COVID-19 include respiratory disturbances and other disabling manifestations,such as fatigue and psychological impairment.To date,there is a paucity of data on the gastrointestinal sequelae of SARS-CoV-2 infection.Since COVID-19 can directly or indirectly affect the gut physiology in different ways,it is plausible that functional bowel diseases may occur after the recovery because of potential pathophysiological alterations(dysbiosis,disruption of the intestinal barrier,mucosal microinflammation,post-infectious states,immune dysregulation and psychological stress).In this review we speculate that COVID-19 can trigger irritable bowel syndrome and we discuss the potential mechanisms.

关 键 词：SARS-CoV-2 COVID-19 Irritable bowel syndrome MICROBIOTA DYSBIOSIS Gut-brain axis 

分 类 号：R563.1[医药卫生—呼吸系统] R574.4[医药卫生—内科学]