Minimally invasive surgery vs laparotomy in patients with colon cancer residing in high-altitude areas  

作　　者：Duo-Ji Suo Lang Yang-Zhen Ci Ren Zha-Xi Bian Ba 

机构地区：[1]Department of General Surgery,People’s Hospital of Tibet Autonomous Region,Lasa 850000,Tibet Autonomous Region,China [2]Department of Internal Medicine,The Tibet Autonomous Region Centers for Disease Control and Prevention,Lasa 850000,Tibet Autonomous Region,China

出　　处：《World Journal of Clinical Cases》2021年第35期10919-10926,共8页世界临床病例杂志

基　　金：the People’s Hospital of Tibet Autonomous Region Institutional Review Board(Approval No.METBHP-21-KJ-025).

摘　　要：BACKGROUND Colon cancer is associated with a higher incidence among residents in highaltitude areas.Hypoxic environment at high altitudes inhibits the phagocytic and oxygen-dependent killing function of phagocytes,thereby increasing the inflammatory factors,inhibiting the body’s innate immunity and increasing the risk of colon cancer.AIM To examine the effect of minimally invasive surgery vs laparotomy in patients with colon cancer residing in high-altitude areas.METHODS Ninety-two patients with colon cancer in our hospital from January 2019 to February 2021 were selected and divided into the minimally invasive surgery and laparotomy groups using the random number table method,with 46 patients in each group.Minimally invasive surgery was performed in the minimally invasive group and laparotomy in the laparotomy group.Operative conditions,inflammatory index pre-and post-surgery,immune function index and complication probability were measured.RESULTS Operative duration was significantly longer and intraoperative blood loss and recovery time of gastrointestinal function were significantly less(all P<0.05)in the minimally invasive group than in the laparotomy group.The number of lymph nodes dissected was not significantly different.Before surgery,there were no significant differences in serum C-reactive protein,interleukin-6 and tumor necrosis factor-αlevels between the groups,whereas after surgery,the levels were significantly higher in the minimally invasive group(26.98±6.91 mg/L,146.38±11.23 ng/mL and 83.51±8.69 pg/mL vs 41.15±8.39 mg/L,186.79±15.36 ng/mL and 110.65±12.84 pg/mL,respectively,P<0.05).Furthermore,before surgery,there were no significant differences in CD3+,CD4+and CD4+/CD8+levels between the groups,whereas after surgery,the levels decreased in both groups,being significantly higher in the minimally invasive group(55.61%±4.39%,35.45%±3.67%and 1.30±0.35 vs 49.68%±5.33%,31.21%±3.25%and 1.13±0.30,respectively,P<0.05).Complication probability was significantly lower in the minimally invasiv

关 键 词：Minimally invasive surgery LAPAROTOMY High-altitude area Colon cancer Surgical trauma Immune dysfunction 

分 类 号：R735.35[医药卫生—肿瘤]