脑部CT在难治性精神分裂症患者中的应用价值  

The application value of cerebral CT in patients with treatment-resistant schizophrenia

作　　者：诸绍锋 程祖胜 戚洪阳 凌迎春[2] ZHU Shaofeng;CHENG Zusheng;QI Hongyang;LING Yingchun(Department of Radiology,Shaoxing 7th People′s Hospital,Zhejiang,Shaoxing 312000,China;Department of Laboratory,Shaoxing 7th People′s Hospital,Zhejiang,Shaoxing 312000,China)

机构地区：[1]浙江省绍兴市第七人民医院放射科,浙江绍兴312000 [2]浙江省绍兴市第七人民医院检验科,浙江绍兴312000

出　　处：《中国现代医生》2021年第29期122-125,F0003,共5页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2019KY723)。

摘　　要：目的探究脑部CT在难治性精神分裂症患者中的应用价值。方法回顾性分析绍兴市第七人民医院在2019年1月至2020年6月期间纳入184例精神分裂症患者的临床资料,将92例难治性精神分裂症患者分为观察组,92例普通精神分裂症患者分为对照组。对所有患者开展脑部CT检查,分析两组CT检查结果、CT影像学特征、临床特征情况以及临床特征与脑萎缩的关系。结果①观察组诊断为脑萎缩46例(56.52%),对照组诊断为脑萎缩3例(3.26%),数据对比差异有统计学意义(χ^(2)=51.430);②对CT影像学特征进行分析,对照组侧脑室异常、皮质异常、髓质异常、脑萎缩、检出透明腔分别为3.26%、13.04%、14.13%、3.26%、22.83%,对照组分别为14.13%、38.04%、35.87%、56.52%、56.52%,组间对比差异有统计学意义(t=6.845、5.717、11.594、51.430、21.822),两组CT影像学中检出最高的是透明腔。③使用明尼苏达多相人格调查表(MMPI评分)分析两组临床特征,观察组社会内向评分、精神衰弱、精神分裂、轻躁狂、偏执、病态人格、癔症、抑郁、疑病评分分别为(60.31±1.52、61.32±2.02、63.57±2.25、63.68±3.58、60.44±1.62、61.58±1.78、62.87±1.46、62.47±1.17、60.74±1.85)分,对照组分别为(52.84±1.03、57.11±2.48、60.35±3.25、55.09±1.67、57.71±2.56、56.34±2.91、60.38±2.85、59.34±0.85、53.38±1.15)分,组间对比数据差异有统计学意义(t=39.023、12.625、7.813、20.857、8.643、14.734、7.458、20.760、32.408)。④观察组出现脑萎缩患者中有40例为分裂性格,对照组出现脑萎缩患者中有3例均为分裂性格。结论难治性精神分裂症患者多办伴发脑萎缩,脑CT临床特征显著,分裂性格患病居多。Objective To investigate the application value of cerebral computed-tomography(CT)in patients with treatment-resistant schizophrenia(TRS).Methods The clinical data of 184 schizophrenic patients included in Shaoxing 7th People′s Hospital from January 2019 to June 2020 were retrospectively analyzed.92 patients with TRS were divided into the observation group and 92 patients with general schizophrenia were divided into the control group.Cerebral CT examination was carried out on all patients,and the CT examination results,CT imaging features,clinical features of and the relationship between clinical features and cerebral atrophy in both groups were analyzed.Results①46 cases(56.52%)were diagnosed with cerebral atrophy in the observation group and 3 cases(3.26%)were diagnosed with cerebral atrophy in the control group,with significant differences in data comparison between the two groups(χ^(2)=51.430).②Analysis of CT imaging features showed that the incidence of lateral ventricular abnormalities,cortical abnormalities,medullary abnormalities,cerebral atrophy,and the detection rate of pseudocele were respectively 3.26%,13.04%,14.13%,3.26%,and 22.83%in the observation group,and those in the control group were 14.13%,38.04%,35.87%,56.52%,and 56.52%,respectively,with statistically significant differences between the two groups(t=6.845,5.717,11.594,51.430,21.822,respectively).The pseudocele was the highest detected in CT imaging of the two groups.③Clinical features of the two groups were analyzed by using the Minnesota Multiphasic Personality Inventory(MMPI score),and the scores of social introversion,psychasthenia,schizophrenia,hypomania,intolerance,pathological personality,hysteria,depression,and hypochondriasis in the observation group were respectively(60.31±1.52,61.32±2.02,63.57±2.25,63.68±3.58,60.44±1.62,61.58±1.78,62.87±1.46,62.47±1.17,60.74±1.85)points,and those in the control group were respectively(52.84±1.03,57.11±2.48,60.35±3.25,55.09±1.67,57.71±2.56,56.34±2.91,60.38±2.85,59.34±0.85,53

关 键 词：脑部CT 难治性分裂症 脑萎缩 性格特征 影响特征 

分 类 号：R749.3[医药卫生—神经病学与精神病学]