JAK2 V617F基因突变及网织血小板数量在骨髓增殖性肿瘤并发血栓性疾病的研究  

Study on JAK2 V617F gene mutation and reticulocyte count in bone marrow proliferative tumors complicated with thrombotic diseases

作　　者：伏俊[1] 任静[1] 昝春梅 严富天 李秀萼 FU Jun;REN Jing;ZAN Chun-mei;YAN FU-tian;LI Xiu-e(Department of Laboratory,Guangyuan Central Hospital;Department of Special Laboratory,Guangyuan Central Hospital;Department of Pathology,Guangyuan Central Hospital;Department of Obstetrics and Gynecology,Guangyuan Hospital of Traditional Chinese Medicine,Guangyuan 628000,Sichuan,China)

机构地区：[1]广元市中心医院检验科 [2]广元市中心医院特检科 [3]广元市中心医院病理科 [4]广元市中医院妇产科,四川广元628000

出　　处：《川北医学院学报》2021年第11期1476-1478,共3页Journal of North Sichuan Medical College

基　　金：四川省广元市科技局(2018ZCZDYF036)。

摘　　要：目的:探究JAK2 V617F基因突变及网织血小板与骨髓增殖性肿瘤(MPN)并发血栓性疾病的相关性。方法:选取132例MPN患者为研究对象,依据是否并发血栓分为病例组(n=82)和血栓组(n=50);另选40名同期体检健康志愿者为对照组。比较三组对象外周血网织血小板计数及MPN患者JAK2V617基因突变情况,分析其与MPN并发血栓性疾病的相关性。结果:血栓组网织血小板计数高于病例组及对照组(P<0.05),且病例组高于对照组(P<0.05)。血栓组JAK2 V617F基因突变阳性率高于病例组(P<0.05)。网织血小板计数及JAK2V617基因突变与血栓的发生呈正相关(P<0.05)。结论:MPN患者并发血栓性疾病与网织血小板计数及JAK2 V617F基因突变有一定的相关性,可能成为评估MPN患者血栓早期发生的实验室检查手段。Objective:To explore the relationship between JAK2 V617F gene mutation and reticulocyte and thrombotic disease in bone marrow proliferative tumor(MPN).Methods:132 patients with MPN were divided into case group(n=82)and thrombus group(n=50)according to whether they were complicated with thrombosis,and 40 healthy volunteers were selected as the control group.The peripheral blood reticulocyte count and JAK2 V617 gene mutation in patients with MPN were compared,and their correlation with MPN complicated with thrombotic diseases was analyzed.Results:The reticulocyte platelet count of thrombus group was higher than that of case group and control group(P<0.05),and the case group was higher than the control group(P<0.05).The positive mutation rate of JAK2 V617 gene in the thrombosis group was higher than that in the case group(P<0.05).There was a positive correlation between reticulocyte platelet and JAK2 V617 gene mutation and thrombosis(P<0.05).Conclusion:Thrombotic diseases in patients with MPN are related to reticulocyte platelet count and JAK2 V617F gene mutation,which may be a laboratory test method to evaluate the early occurrence of thrombosis in patients with MPN.

关 键 词：骨髓增殖性肿瘤 JAK2 V617F基因 网织血小板计数 

分 类 号：R733.3[医药卫生—肿瘤]