Effect of Nephritis Rehabilitation Tablets combined with tacrolimus in treatment of idiopathic membranous nephropathy  

作　　者：Wei Lv Mei-Rong Wang Cheng-Zhen Zhang Xue-Xu Sun Zhen-Zhen Yan Xiao-Min Hu Tao-Tao Wang 

机构地区：[1]Department of Nephology,China People’s Liberation Army 32298,Weifang 261000,Shandong Province,China [2]Department of Pharmacy,China People’s Liberation Army 32298,Weifang 261000,Shandong Province,China [3]Department of Blood Purification,China People’s Liberation Army 32298,Weifang 261000,Shandong Province,China

出　　处：《World Journal of Clinical Cases》2021年第34期10464-10471,共8页世界临床病例杂志

基　　金：the Hospital of No.80 Group Army Institutional Review Board(Approval No.63).

摘　　要：BACKGROUND Idiopathic membranous nephropathy(IMN)has a high incidence in the middleaged and elderly population,and poses a great threat to the physical and mental health and quality of life of patients.Nephritis Rehabilitation Tablets have many potential effects,such as clearing residual toxins,tumefying the kidney and spleen,replenishing qi,and nourishing yin,and have played an important role in the treatment of a variety of kidney diseases.AIM To investigate the efficacy and safety of Nephritis Rehabilitation Tablets combined with tacrolimus in the treatment of IMN.METHODS Eighty-four patients with IMN recruited from January 2017 to September 2020 were randomly divided into a study group(n=42)and a control group(n=42).On the basis of routine symptomatic treatment,both groups were treated with tacrolimus,and the study group was additionally treated with Nephritis Rehabilitation Tablets.Both groups were treated for 12 wk.The therapeutic effect,the levels of renal function indexes[serum creatinine(Scr),serum albumin,and 24-h urinary protein],urinary immunoglobulin(IgG4),membrane attack complex(C5b-9),and the incidence of adverse reactions were measured before and after 12 wk of treatment.RESULTS The total effective rate in the study group was significantly higher than that of the control group.Before treatment,there was no significant difference in Scr,serum albumin,or 24 h urinary protein between the two groups.After 12 wk of treatment,the levels of Scr and 24-h urinary protein in both groups were significantly lower and serum albumin was significantly higher than those before treatment(P<0.05),and the levels of Scr and 24-h urinary protein were significantly lower(P=0.003 and 0.000,respectively),and the level of serum albumin was significantly higher(P=0.00)in the study group than in the control group.Before treatment,there was no significant difference in urinary IgG4 and C5b-9 levels between the study group and the control group(P=0.336 and 0.438,respectively).After 12 wk of treatment,the levels of urinary IgG

关 键 词：Nephritis Rehabilitation Tablets TACROLIMUS Idiopathic membranous nephropathy Renal function IGG4 C5B-9 

分 类 号：R692[医药卫生—泌尿科学]