盐酸纳曲酮联合曲唑酮在海洛因成瘾者脱毒后防复吸中的效果研究  

Effects of naltrexone hydrochloride combined with trazodone on preventing relapse in heroin addicts after detoxification

作　　者：冯枫 徐杰 孙沛 尹露 李洁[5] Feng Feng;Xu Jie;Sun Pei;Yin Lu;Li Jie(No.9 Ward,Suzhou Second People's Hospital,Suzhou 234000,Anhui Province,China;Department of Drug Treatment,Beijing Gaoxin Hospital,Beijing 100021,China;Department of Psychology,School of Social Sciences,Tsinghua University,Beijing 100084,China;Beijing Tiantanghe Compulsory Isolation and Rehabilitation Center,Beijing 102609,China;Department of Biomedical Engineering,School of Medicine,Tsinghua University,Beijing 100084,China)

机构地区：[1]宿州市第二人民医院九病区,安徽省234000 [2]北京高新医院戒毒治疗科,100021 [3]清华大学社会科学学院心理学系,北京100084 [4]北京市天堂河强制隔离戒毒所心理矫治中心,102609 [5]清华大学医学院生物医学工程系,北京100084

出　　处：《中国基层医药》2021年第12期1820-1823,共4页Chinese Journal of Primary Medicine and Pharmacy

基　　金：中国禁毒基金会资助项目(中禁基合字[2016]22号)。

摘　　要：目的探讨盐酸纳曲酮联合曲唑酮在阿片类海洛因成瘾者脱毒后防复吸中的效果。方法选取北京高新医院2016年6月至2019年1月收治的阿片类海洛因兴奋剂成瘾者274例。先采用美沙酮脱毒,然后选取120例采用随机数字表法分为1组(盐酸纳曲酮联合曲唑酮抗复吸治疗6个月)、2组(盐酸纳曲酮抗复吸治疗6个月)各60例,观察两组抗复吸效果。结果两组年龄分布、性别构成、婚姻状况、毒品使用方式等差异均无统计学意义(均P>0.05)。抗复吸治疗6个月后,在个人生活状态不变的情况下,1组未复吸率为86.7%(52/60),2组未复吸率为6.7%(4/60),两组差异有统计学意义(χ^(2)=77.1,P<0.001)。结论盐酸纳曲酮联合曲唑酮在阿片类海洛因成瘾者脱毒后防复吸中的疗效显著优于单独使用盐酸纳曲酮。Objective To investigate the effects of naltrexone hydrochloride combined with trazodone on preventing relapse in heroin addicts after detoxification.Methods A total of 274 opioid heroin addicts who received treatment in Beijing Gaoxin Hospital between June 2016 and January 2019 were included in this study.After detoxification with methadone,all patients were randomly assigned to receive either naltrexone hydrochloride combined with trazodone(group 1,n=60)or naltrexone hydrochloride alone(group 2,n=60)for preventing relapse in heroin addicts.The effects on relapse prevention were determined in each group.Results There were no significant differences in age distribution,sex composition,marital status,and drug use between groups 1 and 2(all P>0.05).After 6 months of treatment,the non-relapse rate was 86.7%(52/60)and 6.7%(4/60)in groups 1 and 2 respectively,in the case of unchanged personal life status.There was significant difference in non-relapse rate between groups 1 and 2(χ^(2)=77.1,P<0.001).Conclusion Naltrexone hydrochloride combined with trazodone exhibits superior efficacy in preventing relapse in opioid heroin addicts after detoxification to naltrexone hydrochloride alone.

关 键 词：阿片生物碱类 海洛因依赖 药物疗法 联合 纳曲酮 曲唑酮 物质戒断综合征 抗复吸 疗效比较研究 

分 类 号：R749.64[医药卫生—神经病学与精神病学]