Anaplastic myxopapillary ependymoma:A case report and review of literature  

作　　者：Hiroshi Kanno Yukiko Kanetsuna Masamichi Shinonaga 

机构地区：[1]Department of Neurosurgery,International University of Health and Welfare Atami Hospital,Atami 413-0012,Shizuoka,Japan [2]Department of Pathology,International University of Health and Welfare Atami Hospital,Atami 413-0012,Shizuoka,Japan

出　　处：《World Journal of Clinical Oncology》2021年第11期1072-1082,共11页世界临床肿瘤学杂志（英文版）

摘　　要：BACKGROUND Myxopapillary ependymoma(MPE)is a pathological grade I tumor that arises in the filum terminale.MPE with anaplastic features is extremely rare,and only 5 cases have shown malignancy at the time of recurrence.CASE SUMMARY The patient(a 46-year-old woman)had undergone a MPE operation 30 years ago.After subtotal resection of the tumor located in L4-S1,it had a solid component that extended to the adjacent subcutaneous region.Histologically,the tumor consisted of a typical MPE with anaplastic features.The anaplastic areas of the tumor showed hypercellularity,a rapid mitotic rate,vascular proliferation,and connective tissue proliferation.Pleomorphic cells and atypical mitotic figures were occasionally observed.The MIB-1 index in this area was 12.3%.The immunohistochemical study showed immunoreactivity for vimentin,glial fibrillary acidic protein and S100.The morphological pattern and immunohistochemical profile were consistent with anaplastic MPE.The patient tolerated surgery well without new neurological deficits.She underwent local irradiation for the residual tumor and rehabilitation.CONCLUSION Although extremely rare,anaplastic MPE occurs in both pediatric and adult patients,similar to other ependymomas.At a minimum,close monitoring is recommended,given concerns about aggressive biological potential.In the future,further study is needed to determine the WHO classification criteria and genetic indicators of tumor progression.The possibility of malignant transformation of MPE should be taken into account,and patients with MPE should be treated with care and follow-up.

关 键 词：Myxopapillary ependymoma Anaplastic feature Pathological feature Clinical feature MANAGEMENT Case report 

分 类 号：R739.4[医药卫生—肿瘤]