Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering  

作　　者：Rui Yu Hualei Zhang Baolin Guo 

机构地区：[1]State Key Laboratory for Mechanical Behavior of Materials,and Frontier Institute of Science and Technology,Xi’an Jiaotong University,Xi’an 710049,People’s Republic of China [2]Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research,College of Stomatology,Xi’an Jiaotong University,Xi’an 710049,People’s Republic of China

出　　处：《Nano-Micro Letters》2022年第1期1-46,共46页纳微快报（英文版）

基　　金：jointly supported by the National Natural Science Foundation of China(Grant Numbers:51973172,and 51673155);the Natural Science Foundation of Shaanxi Province(No.2020JC-03 and 2019TD-020);State Key Laboratory for Mechanical Behavior of Materials;the Fundamental Research Funds for the Central Universities;the World-Class Universities(Disciplines)and the Characteristic Development Guidance Funds for the Central Universities;Opening Project of Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research,College of Stomatology,Xi’an Jiaotong University(No.2019LHM-KFKT008,and No.2021LHM-KFKT005).

摘　　要：Conductive biomaterials based on conductive polymers,carbon nanomaterials,or conductive inorganic nanomaterials demonstrate great potential in wound healing and skin tissue engineering,owing to the similar conductivity to human skin,good antioxidant and antibacterial activities,electrically controlled drug delivery,and photothermal effect.However,a review highlights the design and application of conductive biomaterials for wound healing and skin tissue engineering is lacking.In this review,the design and fabrication methods of conductive biomaterials with various structural forms including film,nanofiber,membrane,hydrogel,sponge,foam,and acellular dermal matrix for applications in wound healing and skin tissue engineering and the corresponding mechanism in promoting the healing process were summarized.The approaches that conductive biomaterials realize their great value in healing wounds via three main strategies(electrotherapy,wound dressing,and wound assessment)were reviewed.The application of conductive biomaterials as wound dressing when facing different wounds including acute wound and chronic wound(infected wound and diabetic wound)and for wound monitoring is discussed in detail.The challenges and perspectives in designing and developing multifunctional conductive biomaterials are proposed as well.

关 键 词：Conducting polymers Inorganic nanomaterials BIOMATERIALS ELECTROTHERAPY Wound monitoring 

分 类 号：R318.08[医药卫生—生物医学工程]