康莱特注射液联合化疗治疗胃癌疗效观察及对肿瘤标志物的影响  

Clinical Observation of Kanglaite Injection Combined with Chemotherapy for Gastric Cancer and Its Effect on Tumor Markers

作　　者：杨爱峰[1] YANG Aifeng

机构地区：[1]濮阳市油田总医院消化内科,河南濮阳457001

出　　处：《新中医》2021年第22期151-154,共4页New Chinese Medicine

摘　　要：目的:观察康莱特注射液联合化疗治疗胃癌的临床疗效及对肿瘤标志物的影响。方法:将胃癌患者80例按随机数字表法分为对照组和观察组各40例。对照组采用紫杉醇、顺铂、5-氟尿嘧啶方案化疗,观察组在对照组的基础上联合康莱特注射液治疗。3个化疗周期后评估2组临床疗效,并比较2组治疗前后癌胚抗原(CEA)、糖类抗原(CA)199、CA125、CA724水平,以及毒副反应发生率。结果:观察组有效率为65.00%,高于对照组的40.00%(P<0.05)。治疗前,2组CEA、CA199、CA125、CA724水平比较,差异无统计学意义(P>0.05);治疗后,2组CEA、CA199、CA125、CA724水平均低于治疗前(P<0.05),且观察组各项指标均低于对照组(P<0.05)。治疗过程中,2组恶心呕吐、血小板降低、白细胞降低、脱发、蛋白尿及肝肾异常发生率比较,差异无统计学意义(P>0.05)。结论:康莱特注射液联合化疗用于胃癌治疗中能获得较好临床疗效,能有效降低肿瘤标志物水平,且不增加毒副反应发生率。Objective:To observe the clinical effect of Kanglaite injection combined with chemotherapy for gastric cancer and its effect on tumor markers.Methods:A total of 80 cases of patients with gastric cancer were divided into the control group and the observation group according to the random number table method,with 40 cases in each group.The control group was given chemotherapy with paclitaxel,cisplatin and 5-fluorouracil,and the observation group was additionally treated with Kanglaite injection based on the treatment of the control group.After three cycles of chemotherapy,the clinical effects in the two groups were evaluated.Before and after treatment,the levels of carcinoembryonic antigen(CEA),carbohydrate antigen(CA)199,CA125 and CA724 as well as the incidence of toxic side effects in the two groups were compared.Results:The effective rate was 65.00%in the observation group,higher than that of 40.00%in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of the levels of CEA,CA199,CA125 and CA724 between the two groups(P>0.05).After treatment,the levels of CEA,CA199,CA125 and CA724 in the two groups were lower than those before treatment(P<0.05),and all the indexes in the observation group were lower than those in the control group(P<0.05).During treatment,there was no significant difference being found in the comparison of the incidences of nausea and vomiting,thrombocytopenia,leukopenia,alopecia,proteinuria and abnormalities in liver and kidney between the two groups(P>0.05).Conclusion:Kanglaite injection combined with chemotherapy for gastric cancer can obtain a good clinical effect and effectively reduce the levels of tumor markers,without increasing the incidence of adverse reactions.

关 键 词：胃癌 化疗 康莱特注射液 肿瘤标志物 毒副反应 

分 类 号：R735.2[医药卫生—肿瘤]