头颈部鳞状细胞癌的免疫治疗进展  

Advances in immunotherapy for head and neck squamous cell carcinoma

作　　者：周琴[1] 张琨 伍海军[1] 闵安杰[2] Zhou Qin;Zhang Kun;Wu Haijun;Min Anjie(Department of Oncology,Xiangya Hospital,Central South Unitersily,Oral Cancer and Precancerous Lesion,MDT in Xiangya Hospital,Changsha 410008,China;Department of Oral and Marillofacial Surgery,Xiangya Hospital,Central South University,Oral Cancer and Precancerous Lesion MDT in Xiangya Hospital,Changsha 410008,China)

机构地区：[1]中南大学湘雅医院肿瘤科,湘雅医院口腔癌及癌前病变MDT,长沙410008 [2]中南大学湘雅医院口腔颌面外科,湘雅医院口腔癌及癌前病变MDT,长沙410008

出　　处：《中国医师杂志》2021年第11期1605-1610,1615,共7页Journal of Chinese Physician

基　　金：湖南省自然科学基金青年项目(2020JJ5957)。

摘　　要：头颈部鳞状细胞癌是头颈部肿瘤最常见的病理类型,可以通过免疫耐受、免疫逃逸、肿瘤细胞高表达免疫检查点分子、T细胞信号破坏等多种机制来逃避免疫应答。近几年来,免疫检查点抑制剂治疗在头颈部鳞状细胞癌患者中取得了突破性进展,从复发转移头颈部鳞癌的二线治疗到一线治疗,再到局部晚期患者的新辅助治疗,均取得了较好的临床`数据。此外,目前正在开展的多种免疫联合疗法如免疫与靶向、免疫与免疫、免疫与放射治疗等也开始崭露头角。然而,由于免疫检查点抑制剂的获益人群仍不明确,如何更合理地将免疫检查点抑制剂与化疗、放疗、靶向治疗以及手术等多种治疗手段有效结合是目前正在探索的方向。在新的个体化治疗时代,头颈部鳞状细胞癌的治疗策略开始出现新的变化,治疗方式越来越丰富的同时也带给我们更多的挑战。在本文中,笔者就近几年开展的免疫治疗应用于头颈部鳞状细胞癌中主要临床研究进行相关综述。Head and neck squamous cell carcinoma(HNSCC)is the most common pathological type in head and neck tumor.It can evade immune response through various mechanisms such as immune tolerance,immune escape,high expression of immune checkpoint molecules in tumor cells and T cell signal destruction.In recent years,immune checkpoint inhibitor therapy has made a breakthrough in HNSCC patients.From second-line therapy to first-line therapy in recurrent and metastatic HNSCC,then adjuvant therapy in locally advanced HNSCC patients,several clinical studies of immune checkpoint inhibitors(ICIs)therapy have been showed good therapeutic effects.In addition,a variely of combination therapies such as ICI combination with targeted therapy,ICI,radiotherapy and other methods currently being studied.However,the beneficiaries of immune checkpoint inhibitors are still unclear,and how to effctively combine immune checkpoint inhibitors with chemotherapy,radiotherapy,targeted therapy and surgery is currently being explored.In the period of indiv idualized treatment,the treatment strategies for HNSCC are experiencing new changes,facing more options and challenges.In this article,we will review some major clinical studies of immune checkpoint inhibitor therapy in squamous cell carcinoma of the head and neck in recent years.

关 键 词：头颈部肿瘤 癌 鳞状细胞 免疫疗法 

分 类 号：R739.91[医药卫生—肿瘤]