NCAM1与口腔扁平苔藓的相关性研究进展  

Research progress of the correlation between NCAM1 and oral lichen planus

作　　者：张松蔚 詹渊博 苗楠 闫颖[1] 王艳[1] 张瑞敏[1] 穆森[1] ZHANG Songwei;ZHAN Yuanbo;MIAO Nan;YAN Ying;WANG Yan;ZHANG Ruimin;MU Sen(Department of Oral Medicine and Periodontics,the Second Affiliated Hospital of Harbin Medical University,Harbin 150086,China)

机构地区：[1]哈尔滨医科大学附属第二医院牙周黏膜科,黑龙江哈尔滨150086

出　　处：《口腔医学》2021年第11期1029-1033,共5页Stomatology

基　　金：国家自然科学基金青年项目(82001488);2019年度黑龙江省省属高等学校基本科研业务费科研项目(2019-KYYWF-0347);2017年度黑龙江省省属高等学校基本科研业务费科研项目(2017LCZX50);黑龙江省卫生计生委科研课题(2017-082)。

摘　　要：神经细胞粘附分子1(neural cell adhesion molecule l,NCAM1)是一种非钙依赖性粘附分子,能介导细胞与细胞、细胞与细胞外基质间的相互作用。在神经系统的发育、免疫细胞功能的调节、细胞的识别及转移、肿瘤的浸润与生长等方面发挥重要作用。近年来的研究表明NCAM1可能参与了口腔扁平苔藓(oral lichen planus,OLP)的发生、发展及癌变过程。本文将从NCAM1的结构、功能及调节,NCAM1在OLP中的异常表达,NCAM1在OLP发生、发展中的可能作用及NCAM1与OLP癌变等方面作一综述。Neural cell adhesion molecule l(NCAM1) is a calcium independent intercellular adhesion molecule, which can mediate the interaction of cell-to-cell and cell-to-matrix. Moreover, it plays an important role in the development of nervous system, the regulation of immune cell function, the recognition and metastasis of cells, and the invasion and growth of tumor. In recent years, studies have shown that NCAM1 may have being involved in the pathogenesis and cancerization of oral lichen planus(OLP).This article will review the research progress on NCAM1 in the following aspects:the structure, function, and regulation of NCAM1, the abnormal expression of NCAM1 in OLP, the possible role of NCAM1 in the occurrence and development of OLP, and NCAM1 and cancerization of OLP.

关 键 词：神经细胞粘附分子1 口腔扁平苔藓 精神因素 免疫因素 

分 类 号：R781.5[医药卫生—口腔医学]