探讨幽门螺杆菌相关难治性胃炎患者Hp耐药性及其根治性治疗方案  

Exploring Hp Drug Resistance and Radical Treatment Options for Patients with Helicobacter Pylori-related Refractory Gastritis

作　　者：郭祥 姚健[1] 杨志[1] 招晋 孙荣[1] GUO Xiang;YAO Jian;YANG Zhi;ZHAO Jin;SUN Rong(Department of Gastroenterology,Jinhu County People's Hospital,Jinhu,Jiangsu Province,211600 China)

机构地区：[1]金湖县人民医院消化内科,江苏金湖211600

出　　处：《系统医学》2021年第20期104-107,共4页Systems Medicine

摘　　要：目的探讨幽门螺杆菌(Hp)相关难治性胃炎患者Hp耐药性及其根治性治疗方案。方法抽取该院2019年1月-2021年6月治疗的222例难治性胃炎患者,设为该研究样本对象。依据抽签规则分为对照组与观察组。对照组有110例,予三联药物治疗;观察组112例,予多药联用方式治疗。评估比对两组治疗效果、碳13呼气试验结果以及各类药物耐药性情况。结果观察组治疗总有效率(96.43%)大幅度高于对照组(83.64%),差异有统计学意义(χ^(2)=10.172,P=0.001);观察组复查碳13呼气试验阴性检出率(92.86%)大幅度高于对照组(78.18%),差异有统计学意义(χ^(2)=9.688,P=0.002);总体药物耐药率(2.68%)大幅度低于对照组(13.64%),差异有统计学意义(χ^(2)=8.943,P=0.003)。结论对难治性胃炎患者实施幽门螺杆菌根除性治疗方案能有效提高治疗效果,提高根治率,减轻患者的耐药性,值得进一步应用和推广。Objective To explore the Hp drug resistance and radical treatment of patients with Helicobacter pylori(Hp)-related refractory gastritis.Methods 222 patients with refractory gastritis who were treated in the hospital were selected from January 2019 to June 2021 as the sample objects of this study.According to the lottery rules,they were divided into a control group and an observation group.110 cases in the control group were treated with triple drugs;112 cases in the observation group were treated with multiple drugs.Assess and compare the treatment effect of the two groups,the results of the carbon 13 breath test,and the drug resistance of various drugs.Results The total effective rate of treatment for the observation group(96.43%)was significantly higher than that of the control group(83.64%),the difference were statistically significant(χ^(2)=10.172,P=0.001);the observation group was reviewed for carbon 13 breath test negative detection rate(92.86%)was significantly higher than that of the control group(78.18%),the difference were statistically significant(χ^(2)=9.688,P=0.002);and the overall drug resistance rate(2.68%)of subjects in this group was significantly lower than the control group(13.64%),the difference were statistically significant(χ^(2)=8.943,P=0.003).Conclusion The eradication of Helicobacter pylori for patients with refractory gastritis can effectively improve the treatment effect,increase the rate of radical cure,and reduce the resistance of patients.It is worthy of further application and promotion.

关 键 词：幽门螺杆菌 难治性胃炎 根治性方案 治疗效果 碳13呼气试验 耐药性 

分 类 号：R573[医药卫生—消化系统]