姑息性手术疗法在晚期胰腺癌患者治疗中的效果和对患者生存质量的影响分析  

Analysis of the Effect of Palliative Surgery in the Treatment of Patients with Advanced Pancreatic Cancer and Its Impact on the Quality of Life of Patients

作　　者：陈建宇[1,2] 钟扬[1,2] 刘志[1,2] CHEN Jianyu;ZHONG Yang;LIU Zhi(The Second Department of Hepatobiliary Surgery,Affiliated Hospital of North Sichuan Medical College,Nanchong,Sichuan Province,637000 China;Hepatobiliary,Pancreatic and Intestinal Research Institute,North Sichuan Medical College,Nanchong,Sichuan Province,637000 China)

机构地区：[1]川北医学院附属医院肝胆外二科,四川南充637000 [2]川北医学院肝胆胰肠研究所,四川南充637000

出　　处：《系统医学》2021年第19期19-22,共4页Systems Medicine

基　　金：南充市市校科技战略合作项目(19SXHZ0309)。

摘　　要：目的探讨姑息性手术疗法在晚期胰腺癌患者治疗中的效果和对患者生存质量的影响观察效果。方法选择2018年10月-2019年10月该院肝胆外二科收治的90例晚期胰腺癌患者作为该研究的对象,将其随机分为两组进行研究,研究组患者(45例)采用姑息性手术进行治疗,对照组患者(45例)采用常规的化疗药物进行对症治疗,并分别对两组患者的治疗效果、生存情况和生存质量的改善效果进行分析和比较。结果研究组患者躯体功能(52.52±4.25)分、认知功能(63.42±6.34)分、角色功能(56.25±4.63)分、情绪功能(63.24±6.35)分、社会功能(57.24±6.24)分和整体功能(63.24±5.25)分均明显高于对照组,差异有统计学意义(t=4.632、9.409、4.416、7.497、11.215、7.092,P<0.05);研究组患者总有效率48.89%高于对照组,差异有统计学意义(χ^(2)=6.983,P<0.05),结论对于提高晚期胰腺癌患者的临床疗效选择采用姑息性手术的方法进行治疗,能够改善生存质量,可以作为晚期胰腺癌患者的首选治疗方法,值得在临床上推广并应用。Objective To investigate the effect of palliative surgery in the treatment of patients with advanced pancreatic cancer and the effect of observation on the quality of life of patients.Methods From October 2018 to October 2019,90 patients with advanced pancreatic cancer admitted to the Second Department of Hepatobiliary Surgery in the hospital were selected as the subjects of this study.They were randomly divided into two groups for the study.Patients in the study group(45 cases)were treated with palliative surgery,and the control group(45 cases)were treated with conventional chemotherapeutics for symptomatic treatment,and the treatment effects,survival conditions and quality of life improvement effects of the two groups of patients were analyzed and compared.Results The study group included physical function(52.52±4.25)points,cognitive function(63.42±6.34)points,and role function(56.25±4.63)points,emotional function(63.24±6.35)points,social function(57.24±6.24)points and overall function(63.24±5.25)points were significantly higher than those of the control group,the difference was statistically significant(t=4.632,9.409,4.416,7.497,11.215,7.092,P<0.05);the total effective rate of patients in the study group was 48.89%,which were higher than that of the control group.The difference was statistically significant(χ^(2)=6.983,P<0.05).Conclusion To improve the clinical efficacy of patients with advanced pancreatic cancer,palliative surgery can be used for treatment,which can improve the quality of life.It can be used as the first choice for the treatment of patients with advanced pancreatic cancer and is worthy of clinical promotion and application.

关 键 词：晚期胰腺癌 姑息性手术 治疗效果 生存质量 

分 类 号：R735.9[医药卫生—肿瘤]