2型糖尿病患者夜间睡眠时间与臂踝脉搏波传导速度的关系  

Relation between sleep duration and brachial-ankle pulse wave velocity in patients with type 2 diabetes mellitus

作　　者：李学毓 郁静嘉 唐雨晨 徐淼[1] 陈艳曙[1] 陈苗 励丽[1] 李佳霖[1] Li Xueyu;Yu Jingjia;Tang Yuchen;Xu Miao;Chen Yanshu;Chen Miao;Li Li;Li Jialin(Department of Endocrinology and Metabolism,Ningbo First Hospital,Ningbo 315010,China)

机构地区：[1]宁波市第一医院内分泌科,315010

出　　处：《中华内分泌代谢杂志》2021年第11期996-1000,共5页Chinese Journal of Endocrinology and Metabolism

摘　　要：探讨2型糖尿病患者夜间睡眠时间与臂踝脉搏波传导速度(baPWV)的关系。收集2018年3月1日至2020年2月29日接受标准化代谢性疾病管理的1755例2型糖尿病患者临床资料和生化指标。按夜间睡眠时长将患者分为短(≤6 h)、中等(>6 h且≤8 h)和长夜间睡眠时间组(>8 h)。baPWV≥1600 cm/s定义为动脉硬化。短、中等和长夜间睡眠时间组baPWV≥1600 cm/s患者的比例分别为39.7%,30.8%和38.6%(P<0.01)。多因素logistic回归分析显示,与中等夜间睡眠时间组相比,长夜间睡眠时间组和短夜间睡眠时间组baPWV≥1600 cm/s的OR值分别为1.317(P<0.05)和1.169(P>0.05)。对性别进行分层,与中等夜间睡眠时间组相比,女性和男性患者长夜间睡眠时间组baPWV≥1600 cm/s的OR值分别为1.735(P<0.05)和1.131(P>0.05)。提示2型糖尿病患者长夜间睡眠时间与baPWV升高有关,两者之间的相关性存在性别差异。To explore the relationship between sleep duration and brachial-ankle pulse wave velocity(baPWV)in patients with type 2 diabetes mellitus(T2DM).A total of 1755 patients with T2DM received standardized management of metabolic disease from March 1,2018 to February 29,2020 were included.All patients were classified into three groups according to the sleep duration:short(≤6 h),medium(>6 h to 8 h)and long(>8 h).Increased arterial stiffness was defined as baPWV≥1600 cm/s.The prevalence of baPWV≥1600 cm/s was 39.7%,30.8%and 38.6%in short,medium and long sleep duration group,respectively(P<0.01).Multivariate logistic regression analysis showed that patients with long sleep duration(OR=1.317,P<0.05)but not short sleep duration(OR=1.169,P>0.05)had a higher risk for baPWV≥1600 cm/s compared with the reference group with medium sleep duration.Stratified analyses by sex showed that the OR were 1.735(P<0.05)among female and 1.131(P>0.05)among male respectively for baPWV≥1600 cm/s in long sleep duration group when compared with medium sleep duration group.Sleep duration>8 h was found to be associated with elevated baPWV in patients with T2DM.There were gender differences in the correlation between long sleep duration and baPWV.

关 键 词：睡眠时间 臂踝脉搏波传导速度 动脉硬化 糖尿病 2型 

分 类 号：R587.1[医药卫生—内分泌]