分析奥美拉唑+奥曲肽治疗肝硬化上消化道出血的效果和对住院时间的影响  

Analysis of the Effect of Omeprazole+Octreotide in the Treatment of Upper Gastrointestinal Bleeding in Liver Cirrhosis and Its Influence on the Length of Hospital Stay

作　　者：丁宁 张志忠[1] 王珊[2] 邓彦俊[1] 赵云华[1] 刘芳睿 张天鹏[1] DING Ning;ZHANG Zhizhong;WANG Shan;DENG Yanjun;ZHAO Yunhua;LIU Fangrui;ZHANG Tianpeng(Emergency Department,Beijing Friendship Hospital,Beijing,100050 China;Department of Geriatrics,Beijing Friendship Hospital,Beijing,100050 China)

机构地区：[1]北京友谊医院急诊科,北京100050 [2]北京友谊医院老年医学科,北京100050

出　　处：《世界复合医学》2021年第10期191-194,共4页World Journal of Complex Medicine

摘　　要：目的分析奥美拉唑+奥曲肽治疗肝硬化上消化道出血的效果和对住院时间的影响。方法选取该院2018年4月—2020年4月收治的80例肝硬化上消化道出血患者按照随机抽签法分为对照组(40例)和干预组(40例)。对照组应用垂体后叶素进行治疗,干预组应用奥美拉唑+奥曲肽进行联合治疗。对比两组治疗有效率、恢复情况、炎症因子以及不良反应。结果干预组治疗效率(95.00%)明显高于对照组(72.50%),差异有统计学意义(χ^(2)=7.439,P<0.05)。干预组的止血时间短于对照组,差异有统计学意义(t=12.254,P<0.05);干预组的住院时间短于对照组,差异有统计学意义(t=9.481,P<0.05);干预组的输血量少于对照组,差异有统计学意义(t=37.748,P<0.05);干预组2 d内再发生出血率(5.00%)低于对照组(25.00%),差异有统计学意义(χ^(2)=6.275,P<0.05)。干预组的IL-6水平、Hs-CRP水平、TNF-α水平均低于对照组,差异有统计学意义(t=10.667、15.594、15.085,P<0.05)。干预组不良反应发生率(2.50%)较于对照组(20.00%)更低,差异有统计学意义(χ^(2)=4.507,P<0.05)。结论奥美拉唑+奥曲肽治疗肝硬化上消化道出血的效果显著,能快速有效地止血,促进患者康复,缩短住院时间,安全性高,值得推广应用。Objective To observe the effect of omeprazole+octreotide in the treatment of upper gastrointestinal bleeding in liver cirrhosis and the influence on the length of hospital stay.Methods A selection of 80 patients with cirrhosis and upper gastrointestinal hemorrhage admitted to the hospital from April 2018 to April 2020 were divided into a control group(40 cases)and an intervention group(40 cases)according to the random lottery method.The control group was treated with pituitrin,and the intervention group was treated with omeprazole+octreotide.The treatment efficiency,recovery,inflammatory factors and adverse reactions of the two groups were compared.Results The treatment efficiency(95.00%)in the intervention group was significantly higher than that in the control group(72.50%),and the difference was statistically significant(χ^(2)=7.439,P<0.05).The hemostasis time in the intervention group was shorter than that in the control group,and the difference was statistically significant(t=12.254,P<0.05);the length of hospitalization in the intervention group was shorter than that in the control group,and the difference was statistically significant(t=9.481,P<0.05);the amount of blood transfusion in the intervention group was less than that in the control group,and the difference was statistically significant(t=37.748,P<0.05),the recurrence bleeding rate within 2 d in the intervention group(5.00%)was lower than that in the control group(25.00%),and the difference was statistically significant(χ^(2)=6.275,P<0.05).The levels of IL-6,Hs-CRP and TNF-αin the intervention group were lower than those in the control group,and the differences were statistically significant(t=10.667,15.594,15.085,P<0.05).The incidence of adverse reactions in the intervention group(2.50%)was lower than that in the control group(20.00%),and the difference was statistically significant(χ^(2)=4.507,P<0.05).Conclusion Omeprazole+octreotide is effective in treating upper gastrointestinal bleeding in liver cirrhosis,can quickly and effectively stop bl

关 键 词：奥美拉唑 奥曲肽 肝硬化 上消化道出血 住院时间 

分 类 号：R575.2[医药卫生—消化系统] R573.2[医药卫生—内科学]